Show simple item record

dc.contributor.authorWeinert, Letícia Schwerzpt_BR
dc.contributor.authorReichelt, Angela de Azevedo Jacobpt_BR
dc.contributor.authorSchmitt, Leonardo Rauberpt_BR
dc.contributor.authorBoff, Robertapt_BR
dc.contributor.authorOppermann, Maria Lúcia Rochapt_BR
dc.contributor.authorCamargo, Joiza Linspt_BR
dc.contributor.authorSilveiro, Sandra Pinhopt_BR
dc.date.accessioned2017-06-02T02:42:15Zpt_BR
dc.date.issued2017pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/159012pt_BR
dc.description.abstractBackground: Gestational diabetes mellitus (GDM) and vitamin D deficiency have been associated with increased risk of adverse perinatal outcomes but the consequences of both conditions simultaneously present in pregnancy have not yet been evaluated. Our objective was to study the influence of vitamin D deficiency in neonatal outcomes of pregnancies with GDM. Methods: 184 pregnant women with GDM referred to specialized prenatal monitoring were included in this cohort and had blood sampled for 25-hydroxyvitamin D measurement. Vitamin D was measured by chemiluminescence and deficiency was defined as < 20 ng/mL. Participants were followed until puerperium and adverse neonatal outcomes were evaluated. Results: Newborns of women with vitamin D deficiency had higher incidences of hospitalization in intensive care units (ICU) (32 vs 19%, P = 0.048), of hypoglycemia (any, 17.3 vs 7.1%, P = 0.039 requiring ICU, 15.3 vs 3.6%, P = 0.008), and were more frequently small for gestational age (SGA) (17.3 vs 5.9%, P = 0.017). After adjustment, relative risk (RR) for hypoglycemia requiring ICU was 3.63 (95%CI 1.09±12.11) and for SGA was 4.32 (95%CI 1.75± 10.66). The incidence of prematurity, jaundice and shoulder dystocia was no statistically different between groups. Conclusions: In this cohort of pregnant women with GDM, vitamin D deficiency was associated with a major increase in the incidence of adverse neonatal outcomes such as SGA newborns and neonatal hypoglycemia.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofPLoS ONE. San Francisco. Vol. 11, no. 10 (Oct. 2016), e0164999, 11 p.pt_BR
dc.rightsOpen Accessen
dc.subjectDiabetes gestacionalpt_BR
dc.subjectDeficiência de vitamina Dpt_BR
dc.subjectRecém-nascido pequeno para a idade gestacionalpt_BR
dc.titleVitamin D deficiency increases the risk of adverse neonatal otcomes in gestational diabetespt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001022808pt_BR
dc.type.originEstrangeiropt_BR


Files in this item

Thumbnail
   

This item is licensed under a Creative Commons License

Show simple item record