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dc.contributor.authorCasanova, Bruna Bentopt_BR
dc.contributor.authorMuniz, Mauro Nevespt_BR
dc.contributor.authorOliveira, Thayse Viana dept_BR
dc.contributor.authorOliveira, Luis Flávio Souza dept_BR
dc.contributor.authorMachado, Michel Mansurpt_BR
dc.contributor.authorFuentefria, Alexandre Meneghellopt_BR
dc.contributor.authorGosmann, Gracept_BR
dc.contributor.authorGnoatto, Simone Cristina Baggiopt_BR
dc.date.accessioned2016-05-04T02:08:06Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn1420-3049pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/140211pt_BR
dc.description.abstractEmerging yeasts are among the most prevalent causes of systemic infections with high mortality rates and there is an urgent need to develop specific, effective and non-toxic antifungal agents to respond to this issue. In this study 35 aldehydes, hydrazones and hydrazines were obtained and their antifungal activity was evaluated against Candida species (C. parapsilosis, C. tropicalis, C. krusei, C. albicans, C. glabrata and C. lusitaneae) and Trichosporon asahii, in an in vitro screening. The minimum inhibitory concentrations (MICs) of the active compounds in the screening was determined against 10 clinical isolates of C. parapsilosis and 10 of T. asahii. The compounds 4-pyridin-2-ylbenzaldehyde] (13a) and tert-butyl-(2Z)-2-(3,4,5-trihydroxybenzylidine)hydrazine carboxylate (7b) showed the most promising MIC values in the range of 16–32 μg/mL and 8–16 μg/mL, respectively. The compounds’ action on the stability of the cell membrane and cell wall was evaluated, which suggested the action of the compounds on the fungal cell membrane. Cell viability ofleukocytes and an alkaline comet assay were performed to evaluate the cytotoxicity. Compound 13a was not cytotoxic at the active concentrations. These results support the discovery of promising candidates for the development of new antifungal agents.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofMolecules. Basel. Vol. 20, no.5 (2015), p. 9229-9241pt_BR
dc.rightsOpen Accessen
dc.subjectAldeidospt_BR
dc.subjectAldehydesen
dc.subjectHydrazonesen
dc.subjectHidrazonaspt_BR
dc.subjectLevedurapt_BR
dc.subjectEmerging yeastsen
dc.subjectAntifungal activityen
dc.subjectAtividade antifúngicapt_BR
dc.titleSynthesis and biological evaluation of hydrazone derivatives as antifungal agentspt_BR
dc.title.alternativeSynthesis and Biological Evaluation of Hydrazone Derivatives as Antifungal Agents en
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000976251pt_BR
dc.type.originEstrangeiropt_BR


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