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dc.contributor.authorRheinheimer, Jakelinept_BR
dc.contributor.authorBauer, Andrea Carlapt_BR
dc.contributor.authorSilveiro, Sandra Pinhopt_BR
dc.contributor.authorEstivalet, Aline Albeche Fariaspt_BR
dc.contributor.authorBouças, Ana Paulapt_BR
dc.contributor.authorRosa, Annelise Ribeiro dapt_BR
dc.contributor.authorSouza, Bianca Marmontel dept_BR
dc.contributor.authorOliveira, Fernanda Santos dept_BR
dc.contributor.authorCruz, Lavínia Almeidapt_BR
dc.contributor.authorBrondani, Letícia de Almeidapt_BR
dc.contributor.authorAzevedo, Mirela Jobim dept_BR
dc.contributor.authorLemos, Natália Emerimpt_BR
dc.contributor.authorCarlessi, Rodrigo Maronpt_BR
dc.contributor.authorAssmann, Taís Silveirapt_BR
dc.contributor.authorGross, Jorge Luizpt_BR
dc.contributor.authorLeitão, Cristiane Bauermannpt_BR
dc.contributor.authorCrispim, Daisypt_BR
dc.date.accessioned2016-01-09T02:41:55Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn2359-4292pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/131685pt_BR
dc.description.abstractType 1 diabetes mellitus (T1DM) is associated with chronic complications that lead to high morbidity and mortality rates in young adults of productive age. Intensive insulin therapy has been able to reduce the likelihood of the development of chronic diabetes complications. However, this treatment is still associated with an increased incidence of hypoglycemia. In patients with “brittle T1DM”, who have severe hypoglycemia without adrenergic symptoms (hypoglycemia unawareness), islet transplantation may be a therapeutic option to restore both insulin secretion and hypoglycemic perception. The Edmonton group demonstrated that most patients who received islet infusions from more than one donor and were treated with steroid-free immunosuppressive drugs displayed a considerable decline in the initial insulin independence rates at eight years following the transplantation, but showed permanent C-peptide secretion, which facilitated glycemic control and protected patients against hypoglycemic episodes. Recently, data published by the Collaborative Islet Transplant Registry (CITR) has revealed that approximately 50% of the patients who undergo islet transplantation are insulin independent after a 3-year follow-up. Therefore, islet transplantation is able to successfully decrease plasma glucose and HbA1c levels, the occurrence of severe hypoglycemia, and improve patient quality of life. The goal of this paper was to review the human islet isolation and transplantation processes, and to describe the establishment of a human islet isolation laboratory at the Endocrine Division of the Hospital de Clínicas de Porto Alegre – Rio Grande do Sul, Brazil.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofArchives of endocrinology and metabolism. São Paulo. Vol. 59, no. 2 (Apr. 2015), p. 161-170pt_BR
dc.rightsOpen Accessen
dc.subjectTransplante das ilhotas pancreáticaspt_BR
dc.subjectHuman pancreatic isletsen
dc.subjectType 1 diabetes mellitusen
dc.subjectDiabetes mellitus tipo 1pt_BR
dc.subjectIslet isolationen
dc.subjectIslet transplantationen
dc.titleHuman pancreatic islet transplantation : an update and description of the establishment of a pancreatic islet isolation laboratorypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000980710pt_BR
dc.type.originNacionalpt_BR


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