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dc.contributor.authorSchlatter, Rosane Paixãopt_BR
dc.contributor.authorMatte, Ursula da Silveirapt_BR
dc.contributor.authorPolanczyk, Carisi Annept_BR
dc.contributor.authorSantos, Patricia Koehler dospt_BR
dc.contributor.authorProlla, Patrícia Ashtonpt_BR
dc.date.accessioned2015-11-11T02:38:56Zpt_BR
dc.date.issued2015pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/129471pt_BR
dc.description.abstractThis study identifies and describes the operating costs associated with the molecular diagnosis of diseases, such as hereditary cancer. To approximate the costs associated with these tests, data informed by Standard Operating Procedures for various techniques was collected from hospital software and a survey of market prices. Costs were established for four scenarios of capacity utilization to represent the possibility of suboptimal use in research laboratories. Cost description was based on a single site. The results show that only one technique was not impacted by rising costs due to underutilized capacity. Several common techniques were considerably more expensive at 30% capacity, including polymerase chain reaction (180%), microsatellite instability analysis (181%), gene rearrangement analysis by multiplex ligation probe amplification (412%), non-labeled sequencing (173%), and quantitation of nucleic acids (169%). These findings should be relevant for the definition of public policies and suggest that investment of public funds in the establishment of centralized diagnostic research centers would reduce costs to the Public Health System.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofGenetics and molecular biology. Ribeirão Preto, SP. Vol. 38, no. 3, (2015), p. 332-337pt_BR
dc.rightsOpen Accessen
dc.subjectMolecular diagnosisen
dc.subjectDiagnostico molecularpt_BR
dc.subjectHereditary canceren
dc.subjectTestes genéticospt_BR
dc.subjectCost analysisen
dc.subjectHereditariedadept_BR
dc.subjectNeoplasiaspt_BR
dc.titleCosts of genetic testing : supporting brazilian public policies for the incorporating of molecular diagnostic technologiespt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000974462pt_BR
dc.type.originNacionalpt_BR


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