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dc.contributor.authorBeck, Ruy Carlos Ruverpt_BR
dc.contributor.authorLionzo, Maria Ismenia Zulianpt_BR
dc.contributor.authorCosta, Tania Maria Haaspt_BR
dc.contributor.authorBenvenutti, Edilson Valmirpt_BR
dc.contributor.authorRé, Maria Inêspt_BR
dc.contributor.authorGallas, Marcia Russmanpt_BR
dc.contributor.authorPohlmann, Adriana Raffinpt_BR
dc.contributor.authorGuterres, Silvia Stanisçuaskipt_BR
dc.date.accessioned2014-11-29T02:20:56Zpt_BR
dc.date.issued2008pt_BR
dc.identifier.issn0104-6632pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/107578pt_BR
dc.description.abstractThis paper was devoted to studying the influence of coating material (nanocapsules or nanospheres), drug model (diclofenac, acid or salt) and method of preparation on the morphological characteristics of nanoparticle-coated microparticles. The cores of microparticles were obtained by spray drying or evaporation and the coating was applied by spray drying. SEM analyses showed nanostructures coating the surface of nanocapsule-coated microparticles and a rugged surface for nanosphere-coated microparticles. The decrease in their surface areas was controlled by the nanoparticulated system, which was not dependent on microparticle size. Optical microscopy and X-ray analyses indicated that acid diclofenac crystals were present in formulations prepared with the acid as well as in the nanocapsule-coated microparticles prepared with the salt. The control of coating is dependent on the use of nanocapsules or nanospheres and independent of either the characteristics of the drug or the method of preparing the core.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of chemical engineering. São Paulo. Vol. 25, n. 2 (Apr./June 2008), p. 389-398pt_BR
dc.rightsOpen Accessen
dc.subjectPolímerospt_BR
dc.subjectCoated microparticlesen
dc.subjectNanoparticlesen
dc.subjectNanopartículaspt_BR
dc.subjectNanocapsulesen
dc.subjectDifração de raios Xpt_BR
dc.subjectSpray dryingen
dc.subjectMicroparticulaspt_BR
dc.subjectX-ray diffractionen
dc.subjectSEMen
dc.titleSurface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery systempt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000650918pt_BR
dc.type.originNacionalpt_BR


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