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dc.contributor.authorPagnussat, Aline de Souzapt_BR
dc.contributor.authorMichaelsen, Stella Marispt_BR
dc.contributor.authorAchaval-Elena, Matildept_BR
dc.contributor.authorIlha, Jocemarpt_BR
dc.contributor.authorHermel, Erica do Espirito Santopt_BR
dc.contributor.authorBack, Franklin Panatopt_BR
dc.contributor.authorNetto, Carlos Alexandrept_BR
dc.date.accessioned2014-08-12T02:10:48Zpt_BR
dc.date.issued2012pt_BR
dc.identifier.issn0100-879Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/100145pt_BR
dc.description.abstractThe most disabling aspect of human peripheral nerve injuries, the majority of which affect the upper limbs, is the loss of skilled hand movements. Activity-induced morphological and electrophysiological remodeling of the neuromuscular junction has been shown to influence nerve repair and functional recovery. In the current study, we determined the effects of two different treatments on the functional and morphological recovery after median and ulnar nerve injury. Adult Wistar male rats weighing 280 to 330 g at the time of surgery (N = 8-10 animals/group) were submitted to nerve crush and 1 week later began a 3-week course of motor rehabilitation involving either “skilled” (reaching for small food pellets) or “unskilled” (walking on a motorized treadmill) training. During this period, functional recovery was monitored weekly using staircase and cylinder tests. Histological and morphometric nerve analyses were used to assess nerve regeneration at the end of treatment. The functional evaluation demonstrated benefits of both tasks, but found no difference between them (P > 0.05). The unskilled training, however, induced a greater degree of nerve regeneration as evidenced by histological measurement (P < 0.05). These data provide evidence that both of the forelimb training tasks used in this study can accelerate functional recovery following brachial plexus injury.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBrazilian journal of medical and biological research. Vol. 45, n. 8 (ago. 2012), p. 753-762pt_BR
dc.rightsOpen Accessen
dc.subjectTraumatismos dos nervos periféricospt_BR
dc.subjectPeripheral nerve injuryen
dc.subjectFunctional recoveryen
dc.subjectRecuperação de função fisiológicapt_BR
dc.subjectNervo medianopt_BR
dc.subjectMedian nerveen
dc.subjectNervo ulnarpt_BR
dc.subjectUlnar nerveen
dc.subjectNerve morphometryen
dc.titleEffect of skilled and unskilled training on nerve regeneration and functional recoverypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000929847pt_BR
dc.type.originNacionalpt_BR


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