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dc.contributor.advisorDalmaz, Carlapt_BR
dc.contributor.authorArcego, Danusa Marpt_BR
dc.date.accessioned2014-06-06T02:06:51Zpt_BR
dc.date.issued2010pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/96145pt_BR
dc.description.abstractEarly life events lead to a large number of behavioral and biochemical alterations in adulthood. The aim of this study is to verify wheter the release of gonadal hormones during puberty affects parameters of oxidative stress observed in adulthood in cerebral cortex, striatum and hypothalamus of female rats subjected to neonatal handling. Rats were exposed or not to neonatal handling (10min/day, first 10 days of life). Between 21-28 post-natal days, females from each litter were divided into the following groups: ovariectomy, sham, and intact (no surgery). When adults, parameters of oxidative stress were analyzed. The groups subjected to surgery (ovx and sham), showed increased production of free radicals by the method of oxidation of dichlorodihydrofluorescein (DCFH) in cerebral cortex and striatum. Decreased catalase activity was observed in the cerebral cortex, in the same groups. No effects of neonatal manipulation were observed in these structures. We conclude that the period after weaning constitute a critical window for stressful interventions during development, leading to alterations in parameters of oxidative stress in adulthood, and these effects are not influenced by estradiol and neonatal handling.en
dc.format.mimetypeapplication/pdf
dc.language.isoporpt_BR
dc.rightsOpen Accessen
dc.subjectEstresse oxidativo : Ratospt_BR
dc.subjectNeonatal handlingen
dc.subjectEstradiolen
dc.subjectOvariectomiapt_BR
dc.subjectManipulação neonatalpt_BR
dc.subjectOxidative stressen
dc.subjectOvariectomyen
dc.subjectSurgical stressen
dc.subjectPre-puberty perioden
dc.titleIntervenções precoces e avaliação de parâmetros oxidativos em diferentes estruturas do sistema nervoso de ratas adultaspt_BR
dc.title.alternativeEarly life interventions: evaluation of oxidative parameters in distinct cns structures in adult female rats en
dc.typeTrabalho de conclusão de graduaçãopt_BR
dc.contributor.advisor-coNoschang, Cristie Grazziotinpt_BR
dc.identifier.nrb000823409pt_BR
dc.degree.grantorUniversidade Federal do Rio Grande do Sulpt_BR
dc.degree.departmentFaculdade de Farmáciapt_BR
dc.degree.localPorto Alegre, BR-RSpt_BR
dc.degree.date2010pt_BR
dc.degree.graduationFarmáciapt_BR
dc.degree.levelgraduaçãopt_BR


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