Mostrar el registro sencillo del ítem

dc.contributor.authorVeit, Tiago Deganipt_BR
dc.contributor.authorCazarolli, Juciana Claricept_BR
dc.contributor.authorSalzano, Francisco Mauropt_BR
dc.contributor.authorSchiengold, Marionpt_BR
dc.contributor.authorChies, Jose Artur Bogopt_BR
dc.date.accessioned2014-02-28T01:50:55Zpt_BR
dc.date.issued2012pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/87995pt_BR
dc.description.abstractHLA-G is a non-classical HLA (Human Leukocyte Antigen) molecule characterized by limited tissue distribution under normal physiological conditions and low variability at both DNA and protein levels. Several studies suggest that HLA-G could play a role, as an immunoregulatory molecule, in situations as diverse as transplantation, cancer, viral infections and inflammatory diseases. A total of 237 individuals from 21 South American tribes speaking nine different linguistic families were studied in relation to the 14 bp insertion/deletion polymorphism at the HLA-G gene. A consistent (seven in nine) excess of heterozygosity in samples classified by language was obtained. Our data supply evidences for balancing selection acting at the HLA-G 14 bp INDEL region. Enhanced fetal survival in a pathogen- rich environment may account for these findings.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofGenetics and molecular biology. Vol. 35, n. 4 supl (Dec. 2012), p. 919-923pt_BR
dc.rightsOpen Accessen
dc.subjectHLA-G 14 bp INDELen
dc.subjectGenéticapt_BR
dc.subjectbalancing selectionen
dc.subjectAmerindiansen
dc.subjectpathogen resistanceen
dc.titleNew evidence for balancing selection at the HLA-G locus in south amerindianspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000876246pt_BR
dc.type.originNacionalpt_BR


Ficheros en el ítem

Thumbnail
   

Este ítem está licenciado en la Creative Commons License

Mostrar el registro sencillo del ítem