High performance liquid chromatography method for quantification of the n-phenylpiperazine derivative lassbio-579 in rat plasma
dc.contributor.author | Conrado, Daniela Joice | pt_BR |
dc.contributor.author | Rates, Stela Maris Kuze | pt_BR |
dc.contributor.author | Dalla Costa, Teresa Cristina Tavares | pt_BR |
dc.contributor.author | Fraga, Carlos Alberto Manssour | pt_BR |
dc.contributor.author | Barreiro, Eliezer J. | pt_BR |
dc.date.accessioned | 2013-07-02T01:43:13Z | pt_BR |
dc.date.issued | 2007 | pt_BR |
dc.identifier.issn | 0100-4042 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/72862 | pt_BR |
dc.description.abstract | A rapid HPLC analytical method was developed and validated for the determination of the N-phenylpiperazine derivative LASSBio- 579 in plasma rat. Analyses were performed using a C18 column and elution with 20 mM sodium dihydrogen phosphate monohydrate-methanol. The analyte was monitored using a photodiode array detector (257 nm). Calibration curves in spiked plasma were linear over the concentration range of 0.3-8 μg/mL with determination coefficient > 0.99. The lower limit of quantification was 0.3 μg/mL. The applicability of the HPLC method for pharmacokinetic studies was tested using plasma samples obtained after administration of LASSBio-579 to Wistar rats, showing the specificity of the method. | en |
dc.format.mimetype | application/pdf | |
dc.language.iso | por | pt_BR |
dc.relation.ispartof | Química nova. São Paulo. Vol. 30, n. 8 (2007), p. 1019-1922 | pt_BR |
dc.rights | Open Access | en |
dc.subject | LASSBio-579 | en |
dc.subject | Cromatografia liquida de alta eficiencia (clae) | pt_BR |
dc.subject | HPLC | en |
dc.subject | LASSBio-579 | pt_BR |
dc.subject | Farmacocinética | pt_BR |
dc.subject | Pharmacokinetics | en |
dc.title | High performance liquid chromatography method for quantification of the n-phenylpiperazine derivative lassbio-579 in rat plasma | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000625742 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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