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dc.contributor.authorCavazzola, Leandro Tottipt_BR
dc.contributor.authorRosa, Andre Ricardo Pereira dapt_BR
dc.contributor.authorSchirmer, Carlos Cauduropt_BR
dc.contributor.authorGurski, Richard Ricachenevskypt_BR
dc.contributor.authorTelles, João Pedro Buenopt_BR
dc.contributor.authorMielke, Fernando Rossipt_BR
dc.contributor.authorMeurer, Luísept_BR
dc.contributor.authorEdelweiss, Maria Isabel Albanopt_BR
dc.contributor.authorKruel, Cleber Dario Pintopt_BR
dc.date.accessioned2013-04-27T01:47:43Zpt_BR
dc.date.issued2009pt_BR
dc.identifier.issn0100-6991pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/70657pt_BR
dc.description.abstractObjetivo: Correlacionar a expressão do p53 e VEGF com o prognóstico de pacientes submetidos à operação curativa para tratar adenocarcinoma do esôfago. Método: Foram estudados 46 pacientes com adenocarcinoma de esôfago, submetidos à ressecções curativas. As expressões do p53 e VEGF foram assessadas por imunoistoquímica em 52.2% e 47.8% dos tumors, respectivamente . Resultados: As expressões de ambos coincidiram em 26% dos casos sem correlação entre elas. Os fatores clinicopatológicos estudados não mostraram correlação significante. Não houve associação significante entre as expresses do p53 e VEGF na sobrevida a longo prazo. Conclusão: As expressões do p53 e VEGF não se correlacionaram com o prognóstico do adenocarcinoma do esôfago nos pacientes operados com ressecções curativas.pt_BR
dc.description.abstractObjectives: To correlate the expression of p53 protein and VEGF with the prognosis of patients submitted to curative resection to treat esophageal adenocarcinoma. Methods: Forty-six patients with esophageal adenocarcinoma, submitted to curative resection, were studied. The expressions of p53 protein and VEGF were assessed by immunohistochemistry in 52.2% and 47.8% of tumors, respectively. Results: P53 protein and VEGF expressions coincided in 26% of the cases, and no correlation between these expressions was observed. None of the clinicopathological factors showed a significant correlation with p53 protein or VEGF expressions. There was no significant association between p53 protein and VEGF expressions and long-term survival. Conclusion: The expression of p53 protein and VEGF did not correlate with prognosis in esophageal adenocarcinoma patients submitted to curative resection.en
dc.format.mimetypeapplication/pdf
dc.language.isoporpt_BR
dc.relation.ispartofRevista do Colégio Brasileiro de Cirurgiões. Rio de Janeiro. Vol. 36, n. 1 (2009), p. 24-34pt_BR
dc.rightsOpen Accessen
dc.subjectNeoplasias esofágicaspt_BR
dc.subjectEsophageal neoplasmsen
dc.subjectGenes p53pt_BR
dc.subjectPrognosisen
dc.subjectGenes p53en
dc.subjectFator A de crescimento do endotélio vascularpt_BR
dc.subjectTaxa de sobrevidapt_BR
dc.subjectVascular endothelial growth factor Aen
dc.subjectSurvivorshipen
dc.titleImmunohistochemical evaluation for P53 and VEGF (Vascular Endothelial Growth Factor) is not prognostic for long term survival in end stage esophageal adenocarcinomapt_BR
dc.title.alternativeAvaliação imunoistoquímica do P53 e VEGF (Fator de Crescimetno Endotelial Vascular) não representa fator prognóstico para sobrevida a longo prazo na fase terminal do adenocarcinoma do esôfago pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000720250pt_BR
dc.type.originNacionalpt_BR


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