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dc.contributor.advisorSchapoval, Elfrides Eva Schermanpt_BR
dc.contributor.authorFühr, Fernandapt_BR
dc.date.accessioned2013-04-10T01:41:35Zpt_BR
dc.date.issued2011pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/70109pt_BR
dc.description.abstractThe carbapenems are a class of -lactam antibiotics that present action against Gram-positive and Gram-negative bacteria. Doripenem is a new carbapenem that has few published studies for the quantitative determination and there isn’t monograph in the Official Codes. Therefore, this study aims to develop and validate microbiological assay for quality control of the drug powder for injectable solution. The parameters analyzed during validation were linearity (r=0.99999), repeatability (RSD=1.74%), intermediate precision (RSD=3.12%), accuracy (98.90 to 101.51%), specificity and robustness. The results show that the method is suitable for quality control of doripenem powder for injectable solution.en
dc.format.mimetypeapplication/pdf
dc.language.isoporpt_BR
dc.rightsOpen Accessen
dc.subjectDoripenempt_BR
dc.subjectDoripenemen
dc.subjectMicrobiological assayen
dc.subjectAntibióticos carbapenêmicospt_BR
dc.subjectStaphylococcus epidermidisen
dc.subjectStaphylococcus epidermidispt_BR
dc.titleDesenvolvimento e validação de doseamento microbiológico por método de difusão em ágar - cilindros em placas para doripenem pó para solução injetávelpt_BR
dc.title.alternativeDevelopment and validation of microbiological assay by agar diffusion method - cylinder plate for doripenem powder for injectable solution en
dc.typeTrabalho de conclusão de graduaçãopt_BR
dc.contributor.advisor-coPaim, Clésio Soldatelipt_BR
dc.identifier.nrb000864921pt_BR
dc.degree.grantorUniversidade Federal do Rio Grande do Sulpt_BR
dc.degree.departmentFaculdade de Farmáciapt_BR
dc.degree.localPorto Alegre, BR-RSpt_BR
dc.degree.date2011pt_BR
dc.degree.graduationFarmáciapt_BR
dc.degree.levelgraduaçãopt_BR


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