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dc.contributor.authorCosta, Sirlei dos Santospt_BR
dc.contributor.authorBlotta, Rosa Mariapt_BR
dc.contributor.authorMeurer, Luísept_BR
dc.contributor.authorEdelweiss, Maria Isabel Albanopt_BR
dc.date.accessioned2012-06-27T01:32:05Zpt_BR
dc.date.issued2011pt_BR
dc.identifier.issn1807-5932pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/49796pt_BR
dc.description.abstractOBJECTIVE: The purpose of this study was to describe the probable mechanism of the volume increase of laparoscopically harvested omentum flaps used to treat breast deformities. METHODS: A histological analysis of omentum samples was performed to study the volume increase of laparoscopically harvested omentum flaps. Samples were harvested immediately after the transposition of the omentum from the abdominal cavity to the breast region and during the second surgical procedure for breast symmetrization of eight patients submitted to the transposition of the omentum flap. Changes in the morphometric measurements of the adipocytes (perimeter, diameter, and area), microvascular density (as measured by the CD31 endothelial marker), and immunohistochemical expression of VEGF were documented. RESULTS: The increases in adipocyte size and microvascular density were statistically significant (P # 0.012). The expression levels of VEGF were lower in the second set of samples when compared to the first set, but the differences were not statistically significant (P , 0.093). CONCLUSION: These results demonstrate an increase in cellular volume as measured by adipocyte perimeter, diameter, and area. Moreover, the increase in the number of vessels in the second set of samples suggests that neoangiogenesis was stimulated by the initial increase in VEGF expression levels observed in the first set of samples. The increase in VEGF expression in the flap may have been caused by adipocyte hypertrophy resulting from neoangiogenesis.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofClinics. São Paulo. Vol. 66, n. 2 (fev. 2011), p. 307-312pt_BR
dc.rightsOpen Accessen
dc.subjectAdipocyteen
dc.subjectAdipócitospt_BR
dc.subjectNeovascularização patológicapt_BR
dc.subjectAngiogenesisen
dc.subjectHipertrofiapt_BR
dc.subjectAdipocyte hypertrophyen
dc.subjectVegfen
dc.subjectAdipose tissueen
dc.titleAdipocyte morphometric evaluation and angiogenesis in the omentum transposed to the breast : a preliminary studypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000778933pt_BR
dc.type.originNacionalpt_BR


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