Mostrar el registro sencillo del ítem

dc.contributor.authorGales, Ana Cristinapt_BR
dc.contributor.authorSader, Hélio S.pt_BR
dc.contributor.authorRibeiro, Julival Fagundespt_BR
dc.contributor.authorZoccoli, Cássiapt_BR
dc.contributor.authorBarth, Afonso Luispt_BR
dc.contributor.authorPignatari, Antonio C.pt_BR
dc.date.accessioned2012-03-23T01:20:57Zpt_BR
dc.date.issued2009pt_BR
dc.identifier.issn1413-8670pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/37824pt_BR
dc.description.abstractWe report the antimicrobial susceptibility patterns of the most frequently isolated Gram-positive bacteria in the Brazilian hospitals participating in the SENTRY Antimicrobial Surveillance Program. The strains were consecutively collected (one per patient) between January 2005 and September 2008 and susceptibility tested by reference broth microdilution methods at the JMI Laboratories (North Liberty, Iowa, USA). A total of 3,907 Gram-positive cocci were analyzed. The Gram-positive organisms most frequently isolated from bloodstream infections were Staphylococcus aureus (2,218 strains; 20.2% of total), coagulase-negative staphylococci (CoNS; 812 strains [14.7%]), and Enterococcus spp. (754 strains; 5.0%). S. aureus ranked first (28.1%) and Enterococcus faecalis ranked 7th (4.5%) among cases of skin and soft tissue infections. S. aureus was also the second most frequently isolated pathogen from patients with lower respiratory tract infections (24.9% of cases) after Pseudomonas aeruginosa (30.5%). Resistance to oxacillin was observed in 31.0% of S. aureus and the vast majority of oxacillin-resistant (MRSA) strains were also resistant to clindamycin, ciprofloxacin and levofloxacin. Vancomycin, linezolid and daptomycin were all very active against S. aureus strains tested (>99.9-100.0% susceptible), but daptomycin (MIC50, 0.25 μg/mL and MIC90, 0.5 μg/mL) was four- to eight-fold more potent than vancomycin (MIC50 and MIC90 of 1 μg/mL) and linezolid (MIC50, 1 μg/mL and MIC90, 2 μg/mL). Vancomycin resistance increased significantly among enterococci during the study period, but it was restrict to only one medical center until 2007 and emerged in a second medical center in 2008. Daptomycin was the most active antimicrobial tested against enterococci in general (100.0% susceptible), followed by linezolid (99.9% susceptible), ampicillin (87.4%) and vancomycin (84.6%). In conclusion, daptomycin and linezolid showed excellent in vitro activity against contemporary Gram-positive organisms (3,907) collected in Brazilian hospitals monitored by the SENTRY Program, including MRSA, vancomycin-resistant enterococci (VRE) and other multidrugresistant organisms. Although vancomycin resistance rates in Brazil appears to be relatively low compared to those reported in the USA, VRE has emerged and rapidly disseminated in some Brazilian medical centers.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofThe Brazilian journal of infectious diseases. Vol. 13, n. 2 (Apr. 2009), p. 90-98pt_BR
dc.rightsOpen Accessen
dc.subjectBacterias gram-positivaspt_BR
dc.subjectAntimicrobial resistanceen
dc.subjectSENTRYen
dc.subjectHospitaispt_BR
dc.subjectNosocomial infectionsen
dc.subjectSuscetibilidade a doençaspt_BR
dc.subjectFarmáciapt_BR
dc.subjectBrazilen
dc.titleAntimicrobial susceptibility of gram-positive bacteria isolated in Brazilian Hospitals Participating in the SENTRY Program (2005-2008)pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000774712pt_BR
dc.type.originNacionalpt_BR


Ficheros en el ítem

Thumbnail
   

Este ítem está licenciado en la Creative Commons License

Mostrar el registro sencillo del ítem