Green propolis phenolic compounds act as vaccine adjuvants, improving humoral and cellular responses in mice inoculated with inactivated vaccines
dc.contributor.author | Fischer, Geferson | pt_BR |
dc.contributor.author | Paulino, Niraldo | pt_BR |
dc.contributor.author | Ribeiro, Maria Cristina Marcucci | pt_BR |
dc.contributor.author | Siedler, Bianca Sica | pt_BR |
dc.contributor.author | Munhoz, Lívia Silveira | pt_BR |
dc.contributor.author | Finger, Paula Fonseca | pt_BR |
dc.contributor.author | Vargas, Gilberto D`Avila | pt_BR |
dc.contributor.author | Hübner, Sílvia de Oliveira | pt_BR |
dc.contributor.author | Vidor, Telmo | pt_BR |
dc.contributor.author | Roehe, Paulo Michel | pt_BR |
dc.date.accessioned | 2011-05-04T06:00:15Z | pt_BR |
dc.date.issued | 2009 | pt_BR |
dc.identifier.issn | 0074-0276 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/28852 | pt_BR |
dc.description.abstract | Adjuvants play an important role in vaccine formulations by increasing their immunogenicity. In this study, the phenolic compound-rich J fraction (JFR) of a Brazilian green propolis methanolic extract stimulated cellular and humoral immune responses when co-administered with an inactivated vaccine against swine herpesvirus type 1 (SuHV-1). When compared to control vaccines that used aluminium hydroxide as an adjuvant, the use of 10 mg/dose of JFR significantly increased (p < 0.05) neutralizing antibody titres against SuHV-1, as well as the percentage of protected animals following SuHV-1 challenge (p < 0.01). Furthermore, addition of phenolic compounds potentiated the performance of the control vaccine, leading to increased cellular and humoral immune responses and enhanced protection of animals after SuHV-1 challenge (p < 0.05). Prenylated compounds such as Artepillin C that are found in large quantities in JFR are likely to be the substances that are responsible for the adjuvant activity. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Memórias do Instituto Oswaldo Cruz : an international journal of biological and biomedical research. Vol. 105, no. 7 (nov. 2010), p. 908-913 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Propolis | en |
dc.subject | Propolis | pt_BR |
dc.subject | Compostos fenólicos | pt_BR |
dc.subject | Phenolic compounds | en |
dc.subject | Vaccines | en |
dc.subject | Vacinas | pt_BR |
dc.subject | Imunidade celular | pt_BR |
dc.subject | Humoral immunity | en |
dc.subject | Imunidade humoral | pt_BR |
dc.subject | Cellular immunity | en |
dc.title | Green propolis phenolic compounds act as vaccine adjuvants, improving humoral and cellular responses in mice inoculated with inactivated vaccines | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 000765451 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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