Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention
dc.contributor.author | Moraes, Greice Graziela | pt_BR |
dc.contributor.author | Reuter, Cézane Priscila | pt_BR |
dc.contributor.author | Renner, Jane Dagmar Pollo | pt_BR |
dc.contributor.author | Klinger, Elisa Inês | pt_BR |
dc.contributor.author | Ferreira, Michele Berger | pt_BR |
dc.contributor.author | Mello, Elza Daniel de | pt_BR |
dc.contributor.author | Valim, Andréia Rosane de Moura | pt_BR |
dc.contributor.author | Burgos, Miria Suzana | pt_BR |
dc.date.accessioned | 2024-12-10T06:54:14Z | pt_BR |
dc.date.issued | 2016 | pt_BR |
dc.identifier.issn | 0001-3765 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/282230 | pt_BR |
dc.description.abstract | Background: Children and adolescents with at-risk genotypes (AA/AT) of the rs9939609 polymorphism in FTO, a fat mass and obesity-associated gene, may exhibit different cardiometabolic profile responses than subjects with the TT genotype after an interdisciplinary intervention. Methods: The sample consisted of 36 school children from southern Brazil. We used DNA quantitation and real-time polymerase chain reaction (PCR) for polymorphism genotyping. We measured anthropometric parameters (body mass index (BMI), waist circumference, hip circumference, waist-hip ratio, body fat percentage and skinfold sum), biochemical parameters (glucose, lipid profile, ultra-sensitive C-reactive protein, uric acid, alanine aminotransferase, aspartate aminotransferase, insulin and adiponectin) and blood pressure. The 4-month intervention consisted of physical education classes, nutritional counseling, and postural and oral health counseling. results: We observed no significant differences among the groups (AA, AT and TT) after the intervention. However, we observed improvements in three parameters (waist circumference, hip circumference and C-reactive protein) in the AT/AA genotype group and in two parameters (hip circumference and uric acid) in the TT genotype group. conclusions: After an intervention program, carriers of at-risk genotypes for obesity (AA/AT) do not exhibit differences in biochemical parameters, blood pressure and anthropometric parameters compared with carriers of the TT genotype. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | por | pt_BR |
dc.relation.ispartof | Anais da Academia Brasileira de Ciências. Rio de Janeiro. Vol. 88, n. 4 (Oct./Dec. 2016), p. 2331-2339 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Polimorfismo genético | pt_BR |
dc.subject | Genotype | en |
dc.subject | Obesidade infantil | pt_BR |
dc.subject | Physical activity | en |
dc.subject | Children | en |
dc.subject | Atividade motora | pt_BR |
dc.subject | Obesity | en |
dc.subject | Intervention | en |
dc.title | Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001015788 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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