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dc.contributor.authorQueiroz, Jaluza Luana Carvalho dept_BR
dc.contributor.authorMedeiros, Isaianept_BR
dc.contributor.authorLima , Mayara Santa Rosapt_BR
dc.contributor.authorCarvalho, Fabiana Maria Coimbra dept_BR
dc.contributor.authorCamillo, Christina da Silvapt_BR
dc.contributor.authorSantos, Pedro Paulo de Andradept_BR
dc.contributor.authorGuerra, Gerlane Coelho Bernardopt_BR
dc.contributor.authorSilva, Valéria C. dapt_BR
dc.contributor.authorSchroeder, Helena Trevisanpt_BR
dc.contributor.authorKrause, Maurício da Silvapt_BR
dc.contributor.authorMorais, Ana Heloneida de Araujopt_BR
dc.contributor.authorPassos, Thaís Souzapt_BR
dc.date.accessioned2024-10-15T06:41:31Zpt_BR
dc.date.issued2023pt_BR
dc.identifier.issn1422-0067pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/280012pt_BR
dc.description.abstractThe present study investigated the effect of gelatin-based nanoparticles (EPG) loaded with a carotenoid-rich crude extract (CE) on systemic and adipose tissue inflammatory response in a model with inflammation induced by a high glycemic index and high glycemic load diet (HGLI). Nanopar- ticles synthesized were characterized by different physical and chemical methods. The in vivo investigation evaluated Wistar rats (n = 20, 11 days, adult male with 21 weeks) subdivided into un- treated (HGLI diet), conventional treatment (nutritionally adequate diet), treatment 1 (HGLI + crude extract (12.5 mg/kg)), and treatment 2 (HGLI + EPG (50 mg/kg)) groups. Dietary intake, caloric intake and efficiency, weight, inflammatory cytokines tissue concentration, visceral adipose tissue (VAT) weight, histopathological analysis, and antioxidant activity in plasma and VAT were inves- tigated. EPG showed the same physical and chemical characteristics as previous batches (95.2 nm, smooth surface, and chemical interactions between materials). The EPG-treated group was the only group promoting negative ∆dietary intake, ∆caloric efficiency, and ∆weight. In addition, it presented a significant reduction (p < 0.05) in IL-6 and leptin levels and a greater presence of multilocular adipocytes. The results suggest that EPG can act as a nutraceutical in adjuvant therapy for treating inflammatory diseases associated with adipose tissue accumulation.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofInternational journal of molecular sciences. Basel. Vol. 24, no. 13 (June 2023), 10657, 24 p.pt_BR
dc.rightsOpen Accessen
dc.subjectNanopartículaspt_BR
dc.subjectCucumis melo L.en
dc.subjectNanoparticlesen
dc.subjectAdiposidadept_BR
dc.subjectAnti-inflamatóriospt_BR
dc.subjectAnti-inflammatory agentsen
dc.subjectAdiposityen
dc.subjectCarotenóidespt_BR
dc.titleEfficacy of carotenoid-loaded gelatin nanoparticles in reducing plasma cytokines and adipocyte hypertrophy in wistar ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001199690pt_BR
dc.type.originEstrangeiropt_BR


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