Mostrar el registro sencillo del ítem

dc.contributor.authorBarbosa, Sílviapt_BR
dc.contributor.authorLaureano, Natalia Koerichpt_BR
dc.contributor.authorHadiwikarta, Wahyu Wijayapt_BR
dc.contributor.authorVisioli, Fernandapt_BR
dc.contributor.authorBonrouhi, Mahnazpt_BR
dc.contributor.authorPajdzik, Kingapt_BR
dc.contributor.authorConde López, Cristinapt_BR
dc.contributor.authorMende, Christel Heroldpt_BR
dc.contributor.authorEidt, Gustavopt_BR
dc.contributor.authorLangie, Renan Cavalheiropt_BR
dc.contributor.authorLamers, Marcelo Lazzaronpt_BR
dc.contributor.authorStögbauer, Fabianpt_BR
dc.contributor.authorHess, Jochenpt_BR
dc.contributor.authorKurth, Inapt_BR
dc.contributor.authorJou, Adrianapt_BR
dc.date.accessioned2024-03-21T05:06:33Zpt_BR
dc.date.issued2024pt_BR
dc.identifier.issn2072-6694pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/273986pt_BR
dc.description.abstractHead and neck squamous cell carcinoma (HNSCC) exhibits considerable variability in patient outcome. It has been reported that SOX2 plays a role in proliferation, tumor growth, drug resis- tance, and metastasis in a variety of cancer types. Additionally, SOX9 has been implicated in immune tolerance and treatment failures. SOX2 and SOX9 induce treatment failure by a molecular mechanism that has not yet been elucidated. This study explores the inverse association of SOX2/SOX9 and their distinct expression in tumors, influencing the tumor microenvironment and radiotherapy responses. Through public RNA sequencing data, human biopsy samples, and knockdown cellular models, we explored the effects of inverted SOX2 and SOX9 expression. We found that patients expressing SOX2LowSOX9High showed decreased survival compared to SOX2HighSOX9Low. A survival analysis of patients stratified by radiotherapy and human papillomavirus brings additional clinical relevance. We identified a gene set signature comprising newly discovered candidate genes resulting from inverted SOX2/SOX9 expression. Moreover, the TGF-β pathway emerges as a significant predicted contributor to the overexpression of these candidate genes. In vitro findings reveal that silencing SOX2 enhances tumor radioresistance, while SOX9 silencing enhances radiosensitivity. These discov- eries lay the groundwork for further studies on the therapeutic potential of transcription factors in optimizing HNSCC treatment.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofCancers. Basel. Vol. 16, no. 2 (Jan. 2024), 439, 25 p.pt_BR
dc.rightsOpen Accessen
dc.subjectNeoplasiaspt_BR
dc.subjectSOX2en
dc.subjectCarcinoma de células escamosas de cabeça e pescoçopt_BR
dc.subjectSOX9en
dc.subjectHNSCCen
dc.subjectMetástase neoplásicapt_BR
dc.subjectHPV negativeen
dc.subjectRadioterapiapt_BR
dc.subjectGene set signatureen
dc.subjectMetastasisen
dc.subjectRadiation treatmenten
dc.titleThe role of SOX2 and SOX9 in radioresistance and tumor recurrencept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001197003pt_BR
dc.type.originEstrangeiropt_BR


Ficheros en el ítem

Thumbnail
   

Este ítem está licenciado en la Creative Commons License

Mostrar el registro sencillo del ítem