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dc.contributor.authorSalgado, Afonso Shiguemi Inouept_BR
dc.contributor.authorTakemoto, Miriam Hatsuept_BR
dc.contributor.authorSouza, Carla Fernanda Tallarico Carvalho dept_BR
dc.contributor.authorSalm, Daiana Cristinapt_BR
dc.contributor.authorRosa, Danielli dapt_BR
dc.contributor.authorCardoso, Gabriela Correapt_BR
dc.contributor.authorLüdtke, Daniela Deropt_BR
dc.contributor.authorSoares, Sílvia Fiorillo Cabrerapt_BR
dc.contributor.authorFerreira, Júlia Koerichpt_BR
dc.contributor.authorDutra, Aline Raulinopt_BR
dc.contributor.authorSzeremeta, Yuri Cordeiropt_BR
dc.contributor.authorMazzardo, Gustavopt_BR
dc.contributor.authorMayra, Joicept_BR
dc.contributor.authorSheffer, Débora da Luzpt_BR
dc.contributor.authorCaumo, Wolneipt_BR
dc.contributor.authorBittencourt, Edsel Balduinopt_BR
dc.contributor.authorSchleip, Robertpt_BR
dc.contributor.authorLatini, Alexandra Susanapt_BR
dc.contributor.authorBobinski, Francianept_BR
dc.contributor.authorMartins, Daniel Fernandespt_BR
dc.date.accessioned2024-01-10T03:36:21Zpt_BR
dc.date.issued2022pt_BR
dc.identifier.issn2077-0383pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/270781pt_BR
dc.description.abstractBackground: Fibromyalgia (FM) is considered a stress-related disorder characterized mainly by chronic widespread pain. Its pathogenesis is unknown, but cumulative evidence points at dysfunctional transmitter systems and inflammatory biomarkers that may underlie the major symptoms of the condition. This study aimed to evaluate pain scores (primary outcome), quality of life, inflammatory biomarkers and neurotransmitter systems in women with FM (secondary outcomes) subjected to gentle touch therapy (GTT) or placebo. Methods: A total of 64 female patients with FM were randomly assigned to two groups, namely GTT (n = 32) or Placebo (n = 32). Clinical assessments were conducted at baseline and post-intervention with six-month follow-up. We measured serum catecholamines (dopamine), indolamines and intermediary metabolites (serotonin or 5-hydroxyindolacetic acid (5-HIAA)), as well as tetrahydrobiopterin (BH4), which is a cofactor for the synthesis of neurotransmitters and inflammatory biomarkers in women with FM. A group of healthy individuals with no intervention (control group) was used to compare biochemical measurements. Intervention effects were analyzed using repeated measures (RM) two-way ANOVA followed by Bonferroni post hoc test and mixed ANCOVA model with intention to treat. Results: Compared to placebo, the GTT group presented lower pain scores and brain-derived neurotrophic factor (BDNF) levels without altering the quality of life of women with FM. Changes in BDNF had a mediating role in pain. Higher baseline serum BDNF and 5-HIAA or those with a history of anxiety disorder showed a higher reduction in pain scores across time. However, women with higher serum dopamine levels at baseline showed a lower effect of the intervention across the observation period revealed by an ANCOVA mixed model. Conclusions: In conclusion, lower pain scores were observed in the GTT group compared to the placebo group without altering the quality of life in women with FM. Reductions in BDNF levels could be a mechanism of FM pain status improvement. In this sense, the present study encourages the use of these GTT techniques as an integrative and complementary treatment of FM.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofJournal of clinical medicine. Basel. Vol. 11, [no. 16] (2022), 4898, 22 p.pt_BR
dc.rightsOpen Accessen
dc.subjectChronic painen
dc.subjectDor crônicapt_BR
dc.subjectInflammatory biomarkersen
dc.subjectBiomarcadorespt_BR
dc.subjectmanual therapyen
dc.subjectManipulações musculoesqueléticaspt_BR
dc.subjectNeurotransmitter systemsen
dc.subjectNeurotransmissorespt_BR
dc.subjectOsteopatiapt_BR
dc.subjectOsteopathic treatmenten
dc.titleGentle Touch Therapy, Pain Relief and Neuroplasticity at Baseline in Fibromyalgia Syndrome : A Randomized, Multicenter Trial with Six-Month Follow-Uppt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001189016pt_BR
dc.type.originEstrangeiropt_BR


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