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dc.contributor.authorBoquett, Juliano Andrépt_BR
dc.contributor.authorVianna, Fernanda Sales Luizpt_BR
dc.contributor.authorFagundes, Nelson Jurandi Rosapt_BR
dc.contributor.authorSchroeder, Lucaspt_BR
dc.contributor.authorBarbian, Márcia Helenapt_BR
dc.contributor.authorOliveira, Marcelo Zagonel dept_BR
dc.contributor.authorAndreis, Tiago Fingerpt_BR
dc.contributor.authorPôrto, Luis Cristóvão de Moraes Sobrinopt_BR
dc.contributor.authorChies, Jose Artur Bogopt_BR
dc.contributor.authorFaccini, Lavinia Schulerpt_BR
dc.contributor.authorProlla, Patrícia Ashtonpt_BR
dc.contributor.authorRosset, Cléviapt_BR
dc.date.accessioned2023-11-30T03:24:53Zpt_BR
dc.date.issued2023pt_BR
dc.identifier.issn0001-3765pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/267857pt_BR
dc.description.abstractThe coronavirus disease 2019 (COVID-19) mortality rates varied among the states of Brazil during the course of the pandemics. The human leukocyte antigen (HLA) is a critical component of the antigen presentation pathway. Individuals with different HLA genotypes may trigger different immune responses against pathogens, which could culminate in different COVID-19 responses. HLA genotypes are variable, especially in the highly admixed Brazilian population. In this ecological study, we aimed to investigate the correlation between HLA haplotypes and the different regional distribution of COVID-19 mortality in Brazil. HLA data was obtained from 4,148,713 individuals registered in The Brazilian Voluntary Bone Marrow Donors Registry. COVID-19 data was retrieved from epidemiological bulletins issued by State Health Secretariats via Brazil’s Ministry of Health from February/2020 to July/2022. We found a positive significant correlation between the HLA-A*01~B*08~DRB1*03 haplotype and COVID-19 mortality rates when we analyzed data from 26 states and the Federal District. This result indicates that the HLAA*01~B*08~DRB1*03 haplotype may represent an additional risk factor for dying due to COVID-19. This haplotype should be further studied in other populations for a better understanding of the variation in COVID-19 outcomes across the world.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofAnais da Academia Brasileira de Ciências. Rio de Janeiro. Vol. 95, no. 3 (2023), e20220801, 9 p.pt_BR
dc.rightsOpen Accessen
dc.subjectVariação genéticapt_BR
dc.subjectCOVID-19 mortalityen
dc.subjectCOVID-19pt_BR
dc.subjectMortalidadept_BR
dc.subjectPredisposição genética para doençapt_BR
dc.subjectSARS-CoV-2pt_BR
dc.subjectBrasilpt_BR
dc.titleHLA haplotypes and differential regional mortality caused by COVID-19 in Brazil : an ecological study based on a large bone marrow donor bank datasetpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001186626pt_BR
dc.type.originNacionalpt_BR


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