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dc.contributor.authorThompson, Claudia Elizabethpt_BR
dc.contributor.authorCorrêa, Lauís Brisolarapt_BR
dc.contributor.authorThompson, Helen Nathaliapt_BR
dc.contributor.authorStassen, Hubert Karlpt_BR
dc.contributor.authorFreitas, Loreta Brandão dept_BR
dc.date.accessioned2023-11-04T03:31:52Zpt_BR
dc.date.issued2023pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/266582pt_BR
dc.description.abstractPlant RNases T2 are involved in several physiological and developmental processes, including inorganic phosphate starvation, senescence, wounding, defense against pathogens, and the self-incompatibility system. Solanaceae RNases form three main clades, one composed exclusively of S-RNases and two that include S-like RNases. We identified several positively selected amino acids located in highly flexible regions of these molecules, mainly close to the B1 and B2 substrate-binding sites in S-like RNases and the hypervariable regions of S-RNases. These differences between S- and S-like RNases in the flexibility of amino acids in substrate-binding regions are essential to understand the RNA-binding process. For example, in the S-like RNase NT, two positively selected amino acid residues (Tyr156 and Asn134) are located at the most flexible sites on the molecular surface. RNase NT is induced in response to tobacco mosaic virus infection; these sites may thus be regions of interaction with pathogen proteins or viral RNA. Differential selective pressures acting on plant ribonucleases have increased amino acid variability and, consequently, structural differences within and among S-like RNases and S-RNases that seem to be essential for these proteins play different functions.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofGenetics and molecular biology. Ribeirão Preto. Vol. 46, no. 1 suppl. 1 (2023), e20220115, 15 p.pt_BR
dc.rightsOpen Accessen
dc.subjectFunctional diversificationen
dc.subjectRibonucleases T2pt_BR
dc.subjectStructural biologyen
dc.subjectSolanaceaept_BR
dc.titleEvolutionary and structural aspects of Solanaceae RNases T2pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001170544pt_BR
dc.type.originNacionalpt_BR


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