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dc.contributor.authorWink, Priscila Lambpt_BR
dc.contributor.authorRamalho, Rafaelapt_BR
dc.contributor.authorMonteiro, Francielle Lizpt_BR
dc.contributor.authorVolpato, Fabiana Caroline Zempulskipt_BR
dc.contributor.authorWillig, Julia Bizpt_BR
dc.contributor.authorLovison, Otávio von Amelnpt_BR
dc.contributor.authorZavascki, Alexandre Prehnpt_BR
dc.contributor.authorBarth, Afonso Luispt_BR
dc.contributor.authorMartins, Andreza Franciscopt_BR
dc.date.accessioned2023-08-01T03:33:33Zpt_BR
dc.date.issued2022pt_BR
dc.identifier.issn2165-0497pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/262918pt_BR
dc.description.abstractThe SARS-CoV-2 P.1 lineage emerged in Amazonas (AM), North Brazil and its evolution has been dynamically reported associated with increased transmissibility and/or immune evasion. Here, we evaluated the lineages circulating in 29 cities in Rio Grande do Sul (RS), Southern Brazil between March 2020 and May 2021 and investigated the genetic events associated with the emergence of the P.1. A total of 202 oro/nasopharyngeal SARS-CoV-2 specimens from patients during routine hospital care were submitted to whole-genome sequencing. Phylogenetic and Bayesian Evolutionary Analyses of the P.1 lineage were carried out to determine the relationship between sequences from RS and AM and dated their common ancestor and origin. One hundred six (53%) sequences were assigned as P.1 and most carried the 22 lineage-defining mutations. All the P.1 sequences included other important mutations, such as P314L and R203K/G204R, and revealed a high genetic diversity in the phylogenetic tree. The time-scaled inference suggests that the oldest P.1 sequences from different Brazilian states share a ancestor with those from AM, but the origin of some sequences from RS is unknown. Further, the common ancestor of sequences from RS is dated to mid-June/July 2020, earlier than those previously reported from AM. Our results demonstrate that there is a high degree of genetic diversity among P.1 sequences, which suggests a continuous evolution and community spread of the virus. Although the first P.1 outbreak was reported in AM, the lineage was associated with multiple introductory events and had already been circulating in Southern Brazil prior to November 2020.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofMicrobiology spectrum. Washington. Vol. 10, n. 1 (2022), e01511-21, p. 1-9pt_BR
dc.rightsOpen Accessen
dc.subjectCOVID-19pt_BR
dc.subjectGammaen
dc.subjectSARS-CoV-2pt_BR
dc.subjectGenomic surveillanceen
dc.subjectP.1 lineageen
dc.subjectGenômicapt_BR
dc.subjectBrasilpt_BR
dc.titleGenomic surveillance of SARS-CoV-2 lineages indicates early circulation of P.1 (gamma) variant of concern in Southern Brazilpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001171653pt_BR
dc.type.originEstrangeiropt_BR


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