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dc.contributor.authorKaminski, Valéria de Limapt_BR
dc.contributor.authorMichita, Rafael Tomoyapt_BR
dc.contributor.authorEllwanger, Joel Henriquept_BR
dc.contributor.authorVeit, Tiago Deganipt_BR
dc.contributor.authorSchuch, Jaqueline Bohrerpt_BR
dc.contributor.authorRiesgo, Rudimar dos Santospt_BR
dc.contributor.authorRoman, Tatianapt_BR
dc.contributor.authorChies, Jose Artur Bogopt_BR
dc.date.accessioned2023-07-21T03:31:20Zpt_BR
dc.date.issued2023pt_BR
dc.identifier.issn2405-8440pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/262544pt_BR
dc.description.abstractAutism Spectrum Disorder (ASD) is a set of neurodevelopmental disorders usually observed in early life, with impacts on behavioral and social skills. Incidence of ASD has been dramatically increasing worldwide, possibly due to increase in awareness/diagnosis as well as to genetic and environmental triggers. Currently, it is estimated that ~1% of the world population presents ASD symptoms. In addition to its genetic background, environmental and immune-related factors also influence the ASD etiology. In this context, maternal immune activation (MIA) has recently been suggested as a component potentially involved in ASD development. In addition, extracellular vesicles (EVs) are abundant at the maternal-fetal interface and are actively involved in the immunoregulation required for a healthy pregnancy. Considering that alterations in concentration and content of EVs have also been associated with ASD, this article raises a debate about the potential roles of EVs in the processes surrounding MIA. This represents the major differential of the present review compared to other ASD studies. To support the suggested correlations and hypotheses, findings regarding the roles of EVs during pregnancy and potential influences on ASD are discussed, along with a review and update concerning the participation of infections, cytokine unbalances, overweight and obesity, maternal anti-fetal brain antibodies, maternal fever, gestational diabetes, preeclampsia, labor type and microbiota unbalances in MIA and ASD.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofHeliyon. London. Vol. 9, no. 5 (May 2023), e15593, 21 p.pt_BR
dc.rightsOpen Accessen
dc.subjectTranstorno do espectro autistapt_BR
dc.subjectAutism spectrum disorderen
dc.subjectImmune systemen
dc.subjectTranstornos do neurodesenvolvimentopt_BR
dc.subjectSistema imunitáriopt_BR
dc.subjectInfectionen
dc.subjectInflammatory responseen
dc.subjectPré-eclâmpsiapt_BR
dc.subjectGestationen
dc.subjectCitocinaspt_BR
dc.subjectCytokinesen
dc.subjectGravidezpt_BR
dc.subjectMaternal immune activationen
dc.subjectMicrobiotapt_BR
dc.subjectPreeclampsiaen
dc.subjectMicrobiotaen
dc.subjectExosomesen
dc.titleExploring potential impacts of pregnancy-related maternal immune activation and extracellular vesicles on immune alterations observed in autism spectrum disorderpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001170950pt_BR
dc.type.originEstrangeiropt_BR


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