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dc.contributor.authorRockenbach, Marília Körbespt_BR
dc.contributor.authorFraga, Lucas Rosapt_BR
dc.contributor.authorKowalski, Thayne Woycinckpt_BR
dc.contributor.authorSanseverino, Maria Teresa Vieirapt_BR
dc.date.accessioned2023-06-17T03:38:01Zpt_BR
dc.date.issued2023pt_BR
dc.identifier.issn1664-8021pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/259135pt_BR
dc.description.abstractGametes are specialized cells that, at fertilization, give rise to a totipotent zygote capable of generating an entire organism. Female and male germ cells undergo meiosis to produce mature gametes; however, sex-specific events of oogenesis and spermatogenesis contribute to specific roles of gametes in reproductive issues. We investigate the differential gene expression (DGE) of meiosis-related genes in human female and male gonads and gametes in normal and pathological conditions. The transcriptome data for the DGE analysis was obtained through the Gene Expression Omnibus repository, comprising human ovary and testicle samples of the prenatal period and adulthood, additionally to male (nonobstructive azoospermia (NOA) and teratozoospermia), and female (polycystic ovary syndrome (PCOS) and advanced maternal age) reproductive conditions. Gene ontology terms related to meiosis were associated with 678 genes, of which 17 genes in common were differentially expressed between the testicle and ovary during the prenatal period and adulthood. Except for SERPINA5 and SOX9, the 17 meiosis-related genes were downregulated in the testicle during the prenatal period and upregulated in adulthood compared to the ovary. No differences were observed in the oocytes of PCOS patients; however, meiosis-related genes were differentially expressed according to the patient’s age and maturity of the oocyte. In NOA and teratozoospermia, 145 meiosis-related genes were differentially expressed in comparison to the control, including OOEP; despite no recognized role in male reproduction, OOEP was co-expressed with genes related to male fertility. Taking together, these results shed light on potential genes that might be relevant to comprehend human fertility disorders.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in genetics. Lausanne. Vol. 14 (Mar. 2023), 1125097, 10 p.pt_BR
dc.rightsOpen Accessen
dc.subjectInfertilidadept_BR
dc.subjectOogenesisen
dc.subjectSpermatogenesisen
dc.subjectOogenesept_BR
dc.subjectGerminal vesicleen
dc.subjectEspermatogênesept_BR
dc.subjectMature oocyteen
dc.subjectInfertilityen
dc.titleExpression profiles of meiotic genes in male vs. female gonads and gametes : insights into fertility issuespt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001166697pt_BR
dc.type.originEstrangeiropt_BR


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