Does preappointment gabapentin affect neurological examination findings? a prospective, randomized and blinded study in healthy cats

Abstract

Objectives The aim of this study was to evaluate the influence of a preappointment oral dose of gabapentin on the neurological examination of cats. Methods A prospective, randomized and blinded clinical trial was conducted in 35 client-owned healthy cats. Cats were scheduled for two appointments and randomly assigned to receive either a placebo or a 100 mg gabapentin capsule prior to the second veterinary visit. A neurological examination was performed during each visit, and the results were compared between groups. Normal/abnormal response rates for each test were based on the number of cats that allowed the test to be performed. Results Gabapentin was administered to 17 cats. Gait and postural reactions were significantly affected in the gabapentin group. Comparing the gabapentin with the placebo groups, proprioceptive ataxia was identified in 4/17(23.5%) vs 0/18 cats (P=0.0288); paw placement deficits were seen in 10/11(90.9%) vs 1/4(25%) cats; table tactile placement deficits were identified in 13/17(76.5%) vs 0/18 cats (P<0.0001); hopping deficits were seen in 5/17(29.4%) vs 0/16 cats (P=0.0185); and abnormalities on wheelbarrowing and extensor postural thrust were reported in 5/17(29.4%) vs 0/18 cats (P=0.0129). These results had no correlation with age or dose/kg received. No significant difference was noted in the assessment of level and content of consciousness, posture, cranial nerves and spinal nerves. No significant differences were noted in test compliance or examination duration. Conclusions and relevance Gabapentin significantly altered gait analyses and postural reactions in this group of healthy cats. The administration of gabapentin could lead to false–positive results and, possibly, an incorrect identification of neurological lesions. In contrast, gabapentin did not impair the assessment of cranial nerves and spinal reflexes, which can be assessed in patients receiving the drug.