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dc.contributor.authorOliveira, Cirilo Henrique dept_BR
dc.contributor.authorCampos, Fabrício Souzapt_BR
dc.contributor.authorFranco, Ana Claudiapt_BR
dc.contributor.authorRoehe, Paulo Michelpt_BR
dc.contributor.authorAbreu, Filipe Vieira Santos dept_BR
dc.date.accessioned2023-04-05T03:47:42Zpt_BR
dc.date.issued2023pt_BR
dc.identifier.issn1999-4915pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/256720pt_BR
dc.description.abstractIn recent decades, waves of yellow fever virus (YFV) from the Amazon Rainforest have spread and caused outbreaks in other regions of Brazil, including the Cerrado, a savannah-like biome through which YFV usually moves before arriving at the Atlantic Forest. To identify the vectors involved in the maintenance of the virus in semiarid environments, an entomological survey was conducted after confirmation of yellow fever (YF) epizootics at the peak of the dry season in the Cerrado areas of the state of Minas Gerais. In total, 917 mosquitoes from 13 taxa were collected and tested for the presence of YFV. Interestingly, mosquitoes of the Sabethes genus represented 95% of the diurnal captured specimens, displaying a peak of biting activity never previously recorded, between 4:30 and 5:30 p.m. Molecular analysis identified three YFV-positive pools, two from Sabethes chloropterus—from which near-complete genomes were generated—and one from Sa. albiprivus, whose low viral load prevented sequencing. Sa. chloropterus was considered the primary vector due to the high number of copies of YFV RNA and the high relative abundance detected. Its bionomic characteristics allow its survival in dry places and dry time periods. For the first time in Brazil, Sa. albiprivus was found to be naturally infected with YFV and may have played a role as a secondary vector. Despite its high relative abundance, fewer copies of viral RNA were found, as well as a lower Minimum Infection Rate (MIR). Genomic and phylogeographic analysis showed that the virus clustered in the sub-lineage YFVPA-MG, which circulated in Pará in 2017 and then spread into other regions of the country. The results reported here contribute to the understanding of the epidemiology and mechanisms of YFV dispersion and maintenance, especially in adverse weather conditions. The intense viral circulation, even outside the seasonal period, increases the importance of surveillance and YFV vaccination to protect human populations in affected areas.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofViruses. Basel. Vol. 15, no. 3 (Mar. 2023), 757, 14 p.pt_BR
dc.rightsOpen Accessen
dc.subjectArbovirusen
dc.subjectFebre amarelapt_BR
dc.subjectMosquito vectoren
dc.subjectVírus da febre amarelapt_BR
dc.subjectCulicidaept_BR
dc.subjectSabethinien
dc.subjectMosquitos vetorespt_BR
dc.subjectGenomic surveillanceen
dc.subjectCerrado, Regiãopt_BR
dc.subjectMinIONen
dc.titleYellow fever virus maintained by Sabethes mosquitoes during the dry season in Cerrado, a Semiarid Region of Brazil, in 2021pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001165592pt_BR
dc.type.originEstrangeiropt_BR


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