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dc.contributor.authorMoraes, Fabiane Pereira dept_BR
dc.contributor.authorMissio, Danielept_BR
dc.contributor.authorLazzari, Jéssicapt_BR
dc.contributor.authorRovani, Monique Tomazelept_BR
dc.contributor.authorFerreira, Rogériopt_BR
dc.contributor.authorGoncalves, Paulo Bayard Diaspt_BR
dc.contributor.authorGasperin, Bernardo Garzierapt_BR
dc.date.accessioned2023-02-10T04:56:38Zpt_BR
dc.date.issued2022pt_BR
dc.identifier.issn1806-9614pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/254593pt_BR
dc.description.abstractThe identification of mutations in the genes encoding bone morphogenetic protein 15 (BMP15) and growth and differentiation factor 9 (GDF9) associated with phenotypes of sterility or increased ovulation rate in sheep aroused interest in the study of the role of local factors in preantral and antral folliculogenesis in different species. An additive mutation in the BMP15 receptor, BMPR1b, which determines an increase in the ovulatory rate, has been introduced in several sheep breeds to increase the number of lambs born. Although these mutations indicate extremely relevant functions of these factors, the literature data on the regulation of the expression and function of these proteins and their receptors are very controversial, possibly due to differences in experimental models. The present review discusses the published data and preliminary results obtained by our group on the participation of local factors in the selection of the dominant follicle, ovulation, and follicular atresia in cattle, focusing on transforming growth factors beta and their receptors. The study of the expression pattern and the functionality of proteins produced by follicular cells and their receptors will allow increasing the knowledge about this local system, known to be involved in ovarian physiopathology and with the potential to promote contraception or increase the ovulation rate in mammals.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofAnimal reproduction. Belo Horizonte. Vol. 19, no. 4 (2022), e20220099, 10 p.pt_BR
dc.rightsOpen Accessen
dc.subjectTransforming growth factorsen
dc.subjectRegulação da expressão gênicapt_BR
dc.subjectDeviationen
dc.subjectProteína morfogenética óssea 15pt_BR
dc.subjectOocyteen
dc.subjectFator 9 de diferenciação de crescimentopt_BR
dc.subjectFoliculogênesept_BR
dc.subjectOvulaçãopt_BR
dc.subjectBovinospt_BR
dc.titleLocal regulation of antral follicle development and ovulation in monovulatory speciespt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001161734pt_BR
dc.type.originNacionalpt_BR


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