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Capsicumicine, a new bioinspired peptide from red peppers prevents staphylococcal biofilm in vitro and in vivo via a matrix anti-assembly mechanism of action
dc.contributor.author | Von Borowski, Rafael Gomes | pt_BR |
dc.contributor.author | Chat, Sophie | pt_BR |
dc.contributor.author | Schneider, Rafael de Oliveira | pt_BR |
dc.contributor.author | Nonin-Lecomte, Sylvie | pt_BR |
dc.contributor.author | Bouaziz, Serge | pt_BR |
dc.contributor.author | Giudice, Emmanuel | pt_BR |
dc.contributor.author | Zimmer, Aline Rigon | pt_BR |
dc.contributor.author | Gnoatto, Simone Cristina Baggio | pt_BR |
dc.contributor.author | Macedo, Alexandre José | pt_BR |
dc.contributor.author | Gillet, Reynald | pt_BR |
dc.date.accessioned | 2023-01-12T04:58:47Z | pt_BR |
dc.date.issued | 2021 | pt_BR |
dc.identifier.issn | 2165-0497 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/253633 | pt_BR |
dc.description.abstract | Staphylococci are pathogenic biofilm-forming bacteria and a source of multidrug resistance and/or tolerance causing a broad spectrum of infections. These bacteria are enclosed in a matrix that allows them to colonize medical devices, such as catheters and tissues, and that protects against antibiotics and immune systems. Advances in antibiofilm strategies for targeting this matrix are therefore extremely relevant. Here, we describe the development of the Capsicum pepper bioinspired peptide “capsicumicine.” By using microbiological, microscopic, and nuclear magnetic resonance (NMR) approaches, we demonstrate that capsicumicine strongly prevents methicillin-resistant Staphylococcus epidermidis biofilm via an extracellular “matrix anti-assembly” mechanism of action. The results were confirmed in vivo in a translational preclinical model that mimics medical device-related infection. Since capsicumicine is not cytotoxic, it is a promising candidate for complementary treatment of infectious diseases. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Microbiology spectrum. Washington. Vol. 9, n. 2 (2021), e00471-21, 16 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Biofilmes | pt_BR |
dc.subject | Antibiofilm | en |
dc.subject | Peptídeos | pt_BR |
dc.subject | Matrix | en |
dc.subject | Peptides | en |
dc.subject | Staphylococcus | pt_BR |
dc.subject | Anti-assembly | en |
dc.subject | Peptídeos antimicrobianos | pt_BR |
dc.subject | Resistance | en |
dc.subject | Tolerance | en |
dc.subject | Antimicrobial peptides | en |
dc.title | Capsicumicine, a new bioinspired peptide from red peppers prevents staphylococcal biofilm in vitro and in vivo via a matrix anti-assembly mechanism of action | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001157608 | pt_BR |
dc.type.origin | Estrangeiro | pt_BR |
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