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dc.contributor.authorMadeira, Francilene B.pt_BR
dc.contributor.authorSilva, Antônio Augusto Moura dapt_BR
dc.contributor.authorVeloso, Helma F.pt_BR
dc.contributor.authorGoldani, Marcelo Zubaranpt_BR
dc.contributor.authorKac, Gilbertopt_BR
dc.contributor.authorCardoso, Viviane C.pt_BR
dc.contributor.authorBettiol, Heloisapt_BR
dc.contributor.authorBarbieri, Marco Antoniopt_BR
dc.date.accessioned2022-11-04T04:38:29Zpt_BR
dc.date.issued2013pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/250744pt_BR
dc.description.abstractObjective: This population-based birth cohort study examined whether normal weight obesity is associated with metabolic disorders in young adults in a middle-income country undergoing rapid nutrition transition. Design and Methods: The sample involved 1,222 males and females from the 1978/79 Ribeira˜o Preto birth cohort, Brazil, aged 23–25 years. NWO was defined as body mass index (BMI) within the normal range (18.5–24.9 kg/m2) and the sum of subscapular and triceps skinfolds above the sex-specific 90th percentiles of the study sample. It was also defined as normal BMI and % BF (body fat) .23% in men and .30% in women. Insulin resistance (IR), insulin sensitivity and secretion were based on the Homeostasis Model Assessment (HOMA) model. Results: In logistic models, after adjusting for age, sex and skin colour, NWO was significantly associated with Metabolic Syndrome (MS) according to the Joint Interim Statement (JIS) definition (Odds Ratio OR = 6.83; 95% Confidence Interval CI 2.84–16.47). NWO was also associated with HOMA2-IR (OR = 3.81; 95%CI 1.57–9.28), low insulin sensitivity (OR = 3.89; 95%CI 2.39–6.33), and high insulin secretion (OR = 2.17; 95%CI 1.24–3.80). Significant associations between NWO and some components of the MS were also detected: high waist circumference (OR = 8.46; 95%CI 5.09–14.04), low High Density Lipoprotein cholesterol (OR = 1.65; 95%CI 1.11–2.47) and high triglyceride levels (OR = 1.93; 95%CI 1.02–3.64). Most estimates changed little after further adjustment for early and adult life variables. Conclusions: NWO was associated with MS and IR, suggesting that clinical assessment of excess body fat in normal-BMI individuals should begin early in life even in middle-income countries.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPloS one. San Francisco. Vol. 8, no. 3 (Mar. 2013), e60673, 9 p.pt_BR
dc.rightsOpen Accessen
dc.subjectObesidadept_BR
dc.subjectSíndrome metabólicapt_BR
dc.subjectAdulto jovempt_BR
dc.subjectResistência à insulinapt_BR
dc.subjectEstudos de coortespt_BR
dc.subjectRibeirão Preto (SP)pt_BR
dc.titleNormal weight obesity is associated with metabolic syndrome and insulin resistance in young adults from a middle-income countrypt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000908014pt_BR
dc.type.originEstrangeiropt_BR


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