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dc.contributor.authorGBD 2019 Diabetes and Air Pollution Collaboratorspt_BR
dc.contributor.authorDuncan, Bruce Bartholowpt_BR
dc.contributor.authorSchmidt, Maria Inêspt_BR
dc.date.accessioned2022-10-27T04:52:19Zpt_BR
dc.date.issued2022pt_BR
dc.identifier.issn2525-4863pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/250474pt_BR
dc.description.abstractBackground Experimental and epidemiological studies indicate an association between exposure to particulate matter (PM) air pollution and increased risk of type 2 diabetes. In view of the high and increasing prevalence of diabetes, we aimed to quantify the burden of type 2 diabetes attributable to PM2·5 originating from ambient and household air pollution. Methods We systematically compiled all relevant cohort and case-control studies assessing the effect of exposure to household and ambient fine particulate matter (PM2·5) air pollution on type 2 diabetes incidence and mortality. We derived an exposure–response curve from the extracted relative risk estimates using the MR-BRT (meta-regression—Bayesian, regularised, trimmed) tool. The estimated curve was linked to ambient and household PM2·5 exposures from the Global Burden of Diseases, Injuries, and Risk Factors Study 2019, and estimates of the attributable burden (population attributable fractions and rates per 100 000 population of deaths and disability-adjusted life-years) for 204 countries from 1990 to 2019 were calculated. We also assessed the role of changes in exposure, population size, age, and type 2 diabetes incidence in the observed trend in PM2·5-attributable type 2 diabetes burden. All estimates are presented with 95% uncertainty intervals. Findings In 2019, approximately a fifth of the global burden of type 2 diabetes was attributable to PM2·5 exposure, with an estimated 3·78 (95% uncertainty interval 2·68–4·83) deaths per 100 000 population and 167 (117–223) disability-adjusted life-years (DALYs) per 100 000 population. Approximately 13·4% (9·49–17·5) of deaths and 13·6% (9·73–17·9) of DALYs due to type 2 diabetes were contributed by ambient PM2·5, and 6·50% (4·22–9·53) of deaths and 5·92% (3·81–8·64) of DALYs by household air pollution. High burdens, in terms of numbers as well as rates, were estimated in Asia, sub-Saharan Africa, and South America. Since 1990, the attributable burden has increased by 50%, driven largely by population growth and ageing. Globally, the impact of reductions in household air pollution was largely offset by increased ambient PM2·5. Interpretation Air pollution is a major risk factor for diabetes. We estimated that about a fifth of the global burden of type 2 diabetes is attributable PM2·5 pollution. Air pollution mitigation therefore might have an essential role in reducing the global disease burden resulting from type 2 diabetes.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofThe lancet planetary health. Amsterdam. Vol. 6, no. 7 (2022), p. e586-e600.pt_BR
dc.rightsOpen Accessen
dc.subjectCarga global da doençapt_BR
dc.subjectDiabetes mellitus tipo 2pt_BR
dc.subjectPoluição do arpt_BR
dc.titleEstimates, trends, and drivers of the global burden of type 2 diabetes attributable to PM2·5 air pollution, 1990–2019 : an analysis of data from the Global Burden of Disease Study 2019pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001151293pt_BR
dc.type.originEstrangeiropt_BR


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