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dc.contributor.authorJannasch, Franziskapt_BR
dc.contributor.authorLuft, Vivian Cristinept_BR
dc.contributor.authorSchulze, Matthias B.pt_BR
dc.date.accessioned2022-10-26T04:49:48Zpt_BR
dc.date.issued2022pt_BR
dc.identifier.issn1436-6215pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/250363pt_BR
dc.description.abstractPurpose In several studies, exploratory dietary patterns (DP), derived by principal component analysis, were inversely or positively associated with incident type 2 diabetes (T2D). However, fndings remained study-specifc, inconsistent and rarely replicated. This study aimed to investigate the associations between DPs and T2D in multiple cohorts across the world. Methods This federated meta-analysis of individual participant data was based on 25 prospective cohort studies from 5 continents including a total of 390,664 participants with a follow-up for T2D (3.8–25.0 years). After data harmonization across cohorts we evaluated 15 previously identifed T2D-related DPs for association with incident T2D estimating pooled incidence rate ratios (IRR) and confdence intervals (CI) by Piecewise Poisson regression and random-efects meta-analysis. Results 29,386 participants developed T2D during follow-up. Five DPs, characterized by higher intake of red meat, processed meat, French fries and refned grains, were associated with higher incidence of T2D. The strongest association was observed for a DP comprising these food groups besides others (IRRpooled per 1 SD=1.104, 95% CI 1.059–1.151). Although heterogeneity was present (I 2=85%), IRR exceeded 1 in 18 of the 20 meta-analyzed studies. Original DPs associated with lower T2D risk were not confrmed. Instead, a healthy DP (HDP1) was associated with higher T2D risk (IRRpooled per 1 SD=1.057, 95% CI 1.027–1.088). Conclusion Our fndings from various cohorts revealed positive associations for several DPs, characterized by higher intake of red meat, processed meat, French fries and refned grains, adding to the evidence-base that links DPs to higher T2D risk. However, no inverse DP–T2D associations were confrmed.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofEuropean journal of nutrition. Darmstadt. Vol. 61 (2022), p. 3649-3667.pt_BR
dc.rightsOpen Accessen
dc.subjectDiabetes mellitus tipo 2pt_BR
dc.subjectDietary patternsen
dc.subjectExploratoryen
dc.subjectMetanálisept_BR
dc.subjectType 2 diabetes mellitusen
dc.subjectDietapt_BR
dc.subjectFederated meta-analysisen
dc.titleAssociations between exploratory dietary patterns and incident type 2 diabetes : a federated meta-analysis of individual participant data from 25 cohort studiespt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001150085pt_BR
dc.type.originEstrangeiropt_BR


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