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dc.contributor.authorSehn, Ana Paulapt_BR
dc.contributor.authorBrand, Carolinept_BR
dc.contributor.authorSilveira, João Francisco de Castropt_BR
dc.contributor.authorAndersen, Lars Bopt_BR
dc.contributor.authorGaya, Anelise Reispt_BR
dc.contributor.authorTodendi, Pâmela Ferreirapt_BR
dc.contributor.authorValim, Andréia Rosane de Mourapt_BR
dc.contributor.authorReuter, Cézane Priscilapt_BR
dc.date.accessioned2022-09-01T05:00:14Zpt_BR
dc.date.issued2022pt_BR
dc.identifier.issn1471-2261pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/248394pt_BR
dc.description.abstractBackground: Genetic factors along with inadequate lifestyle habits are associated with the development of cardiometabolic alterations. Thus, the present study aimed to examine the role of sedentary behavior on the relationship between rs9939609 polymorphism (fat mass and obesity-associated gene-FTO) and cardiometabolic risk score according to cardiorespiratory ftness (CRF) levels in children and adolescents. Methods: A cross-sectional study with 1215 children and adolescents (692 girls), aged between 6 and 17 years. Screen time as a marker of sedentary behavior was evaluated through a self-reported questionnaire and CRF was estimated using the 6-min walking and running test. The genotyping of the FTO rs9939609 polymorphism was performed using a real-time polymerase chain reaction. Clustered cardiometabolic risk score (cMetS) was calculated by summing z-scores of total cholesterol/high-density lipoprotein cholesterol ratio, triglycerides, glucose, systolic blood pressure, and waist circumference, and dividing it by fve. Moderation analyses were tested using multiple linear regression models. Results: The coefcient of the interaction term of FTO (rs9939609) and screen time indicated that screen time was a signifcant moderator on the relationship between FTO rs9939609 polymorphism and cMetS (p=0.047) in children and adolescents classifed with low CRF (β=0.001; 95% CI=0.001; 0.002). It was observed a signifcant association between genotype risk (AA) of FTO polymorphism and cMetS, in participants that spent more than 378 min a day in front of screen-based devices (β=0.203; 95% CI=0.000; 0.405). No interaction term was found for those with high CRF. Conclusions: High sedentary behavior seems to infuence the relationship between genetic predisposition to obesity and cardiometabolic risk factors in children and adolescents with low CRF.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBMC Cardiovascular Disorders. London. v. 22 (2022), 92, p. 1-9.pt_BR
dc.rightsOpen Accessen
dc.subjectComportamento sedentáriopt_BR
dc.subjectScreen timeen
dc.subjectObesidadept_BR
dc.subjectCardiorespiratory ftnessen
dc.subjectFTO polymorphismen
dc.subjectAptidão cardiorrespiratóriapt_BR
dc.subjectMetabolic syndromeen
dc.subjectCriançaspt_BR
dc.subjectAdolescentespt_BR
dc.subjectChildhooden
dc.subjectPolimorfismopt_BR
dc.subjectYoungen
dc.subjectSíndrome metabólicapt_BR
dc.titleWhat is the role of cardiorespiratory fitness and sedentary behavior in relationship between the genetic predisposition to obesity and cardiometabolic risk score?pt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001145960pt_BR
dc.type.originEstrangeiropt_BR


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