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dc.contributor.authorZielinsky, Paulopt_BR
dc.contributor.authorMartignoni, Felipe Villapt_BR
dc.contributor.authorMarkoski, Melissa Medeirospt_BR
dc.contributor.authorZucatti, Kelly Pozzerpt_BR
dc.contributor.authorMarinho, Gabriela dos Santospt_BR
dc.contributor.authorPozzobon, Gabriela Felipettopt_BR
dc.contributor.authorMagno, Pedro Rafaelpt_BR
dc.contributor.authorAntunes, Victória de Bittencourtpt_BR
dc.contributor.authorSulis, Natássia Mirandapt_BR
dc.contributor.authorCardoso, Alexandra Seidept_BR
dc.contributor.authorMattos, Daniel Rochapt_BR
dc.contributor.authorNaujorks, Alexandre Antoniopt_BR
dc.contributor.authorFrankenberg, Anize Delfino vonpt_BR
dc.contributor.authorCôrrea, Izabele Vian da Silveirapt_BR
dc.date.accessioned2022-08-21T04:40:11Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn2045-2322pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/247698pt_BR
dc.description.abstractMaternal consumption of polyphenol-rich foods has been associated with fetal ductus arteriosus constriction (DAC), but safety of chocolate exposure in fetal life has not been studied. This experimental study tested the hypothesis that maternal cocoa consumption in late pregnancy causes fetal DAC, with possible associated antioxidant effects. Pregnant Wistar rats, at the 21st gestational day, received by orogastric tube cocoa (720 mg/Kg) for 12 h, indomethacin (10 mg/Kg), for 8 h, or only water, before cesaren section. Immediately after withdrawal, every thorax was obtained and tissues were fixed and stained for histological analysis. The ratio of the narrowest part of the pulmonary artery to the fetal ductus inner diameter and increased ductal inner wall thickness characterized ductal constriction. Substances reactive to thiobarbituric acid were quantified. Statistical analysis used ANOVA and Tukey test. Cocoa (n = 33) and indomethacin (n = 7) reduced fetal internal ductus diameter when compared to control (water, n = 25) (p < 0.001) and cocoa alone increased ductus wall thickness (p < 0.001), but no change was noted in enzymes activity. This pharmacological study shows supporting evidences that there is a cause and effect relationship between maternal consumption of cocoa and fetal ductus arteriosus constriction. Habitual widespread use of chocolate during gestation could account for undetected ductus constriction and its potentially severe consequences, such as perinatal pulmonary hypertension, cardiac failure and even death. For this reason, dietary guidance in late pregnancy to avoid high chocolate intake, to prevent fetal ductal constriction, may represent the main translational aspect of this study.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofScientific reports. London. Vol. 11 (2021), 9929, [7 p.]pt_BR
dc.rightsOpen Accessen
dc.subjectCanal arterialpt_BR
dc.subjectFetopt_BR
dc.subjectRatos Wistarpt_BR
dc.subjectPolifenóispt_BR
dc.subjectCacaupt_BR
dc.titleMaternal ingestion of cocoa causes constriction of fetal ductus arteriosus in ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001147765pt_BR
dc.type.originEstrangeiropt_BR


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