Show simple item record

dc.contributor.authorDominguez-Bello, Maria G.pt_BR
dc.contributor.authorPérez, Maria E.pt_BR
dc.contributor.authorBortolini, Maria Cátirapt_BR
dc.contributor.authorSalzano, Francisco Mauropt_BR
dc.contributor.authorPericchi, Luis R.pt_BR
dc.contributor.authorZambrano-Guzmán, Orlisbethpt_BR
dc.contributor.authorLinz, Bodopt_BR
dc.date.accessioned2010-07-15T04:18:12Zpt_BR
dc.date.issued2008pt_BR
dc.identifier.issn1932-6203pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/24629pt_BR
dc.description.abstractWe studied the diversity of bacteria and host in the H. pylori-human model. The human indigenous bacterium H. pylori diverged along with humans, into African, European, Asian and Amerindian groups. Of these, Amerindians have the least genetic diversity. Since niche diversity widens the sets of resources for colonizing species, we predicted that the Amerindian H. pylori strains would be the least diverse. We analyzed the multilocus sequence (7 housekeeping genes) of 131 strains: 19 cultured from Africans, 36 from Spanish, 11 from Koreans, 43 from Amerindians and 22 from South American Mestizos. We found that all strains that had been cultured from Africans were African strains (hpAfrica1), all from Spanish were European (hpEurope) and all from Koreans were hspEAsia but that Amerindians and Mestizos carried mixed strains: hspAmerind and hpEurope strains had been cultured from Amerindians and hpEurope and hpAfrica1 were cultured from Mestizos. The least genetically diverse H. pylori strains were hspAmerind. Strains hpEurope were the most diverse and showed remarkable multilocus sequence mosaicism (indicating recombination). The lower genetic structure in hpEurope strains is consistent with colonization of a diversity of hosts. If diversity is important for the success of H. pylori, then the low diversity of Amerindian strains might be linked to their apparent tendency to disappear. This suggests that Amerindian strains may lack the needed diversity to survive the diversity brought by non-Amerindian hosts.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofPLoS One. San Francisco. Vol. 3, no.10 (oct. 2008), e3307, 7 p.pt_BR
dc.rightsOpen Accessen
dc.subjectGenética humanapt_BR
dc.subjectHelicobacter pyloript_BR
dc.subjectAmeríndiospt_BR
dc.subjectAmérica Latinapt_BR
dc.titleAmerindian Helicobacter pylori strains go extinct, as european strains expand their host rangept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000686524pt_BR
dc.type.originEstrangeiropt_BR


Files in this item

Thumbnail
   

This item is licensed under a Creative Commons License

Show simple item record