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dc.contributor.authorFaccini, Lavinia Schulerpt_BR
dc.contributor.authorBoquett, Juliano Andrépt_BR
dc.contributor.authorKowalski, Thayne Woycinckpt_BR
dc.contributor.authorGerzson, Laís Rodriguespt_BR
dc.contributor.authorAlmeida, Carla Skilhan dept_BR
dc.contributor.authorSanti, Lucéliapt_BR
dc.contributor.authorSilva, Walter Orlando Beys dapt_BR
dc.contributor.authorQuincozes-Santos, Andrépt_BR
dc.contributor.authorGomes, Julia do Amaralpt_BR
dc.contributor.authorVianna, Fernanda Sales Luizpt_BR
dc.contributor.authorFraga, Lucas Rosapt_BR
dc.contributor.authorRosa, Rafael Lopes dapt_BR
dc.contributor.authorAbeche, Alberto Mantovanipt_BR
dc.contributor.authorSouza, Diogo Onofre Gomes dept_BR
dc.date.accessioned2022-06-07T04:39:12Zpt_BR
dc.date.issued2022pt_BR
dc.identifier.issn1664-8021pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/239804pt_BR
dc.description.abstractFive years after the identification of Zika virus as a human teratogen, we reviewed the early clinical manifestations, collectively called congenital Zika syndrome (CZS). Children with CZS have a very poor prognosis with extremely low performance in motor, cognitive, and language development domains, and practically all feature severe forms of cerebral palsy. However, these manifestations are the tip of the iceberg, with some children presenting milder forms of deficits. Additionally, neurodevelopment can be in the normal range in the majority of the non-microcephalic children born without brain or eye abnormalities. Vertical transmission and the resulting disruption in development of the brain are much less frequent when maternal infection occurs in the second half of the pregnancy. Experimental studies have alerted to the possibility of other behavioral outcomes both in prenatally infected children and in postnatal and adult infections. Cofactors play a vital role in the development of CZS and involve genetic, environmental, nutritional, and social determinants leading to the asymmetric distribution of cases. Some of these social variables also limit access to multidisciplinary professional treatment.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in genetics. Lausanne. Vol. 13 (Mar. 2022), 758715, 18 p.pt_BR
dc.rightsOpen Accessen
dc.subjectMicrocephalyen
dc.subjectInfecção por Zika viruspt_BR
dc.subjectManifestações neurológicaspt_BR
dc.subjectZika (ZIKV)en
dc.subjectEpilepsyen
dc.subjectTranstornos do neurodesenvolvimentopt_BR
dc.subjectCriançapt_BR
dc.subjectCerebral palsyen
dc.subjectNeurodevelopementen
dc.subjectDeficiências do desenvolvimentopt_BR
dc.subjectEyeen
dc.titleNeurodevelopment in children exposed to Zika in utero : clinical and molecular aspectspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001141096pt_BR
dc.type.originEstrangeiropt_BR


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