Synthesis and characterization of phloroglucinol derivatives
Fecha
2018Tutor
Co-director
Nivel académico
Grado
Tipo
Materia
Abstract
Phloroglucinol derivatives have been proved to have great pharmacological activity. Two acylated phloroglucinol were synthesized by Friedel-Crafts reaction and characterized by High Performance Liquid Chromatography (HPLC), Differential Scanning Calorimetry (DSC) , mass spectroscopy and Nuclear Magnetic Resonance (NMR) . The one-step synthesis was considered simple, giving a yield for 68% of monoacylphloroglucinol (MAPG) and 32% for diacylphloroglucinol (DAPG). Purification by crystallization o ...
Phloroglucinol derivatives have been proved to have great pharmacological activity. Two acylated phloroglucinol were synthesized by Friedel-Crafts reaction and characterized by High Performance Liquid Chromatography (HPLC), Differential Scanning Calorimetry (DSC) , mass spectroscopy and Nuclear Magnetic Resonance (NMR) . The one-step synthesis was considered simple, giving a yield for 68% of monoacylphloroglucinol (MAPG) and 32% for diacylphloroglucinol (DAPG). Purification by crystallization of DAPG was more efficient than column chromatography of MAPG, showing great results after analysis. The analytical methods used in this work have proven to be simple and efficient to characterize both compounds, resulting in important information to proceed in the search of novel therapies. ...
Institución
Universidade Federal do Rio Grande do Sul. Faculdade de Farmácia. Curso de Farmácia.
Colecciones
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Tesinas de Curso de Grado (36369)Tesinas Farmacia (676)
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