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dc.contributor.authorSantos, Bernardo Gindri dospt_BR
dc.contributor.authorKlein, Caroline Perespt_BR
dc.contributor.authorCrestani, Mariana Scortegagnapt_BR
dc.contributor.authorMaurmann, Rafael Mourapt_BR
dc.contributor.authorHözer, Régis Mateuspt_BR
dc.contributor.authorRodrigues, Karoline dos Santospt_BR
dc.contributor.authorAugust, Pauline Macielpt_BR
dc.contributor.authorMatté, Cristianept_BR
dc.date.accessioned2022-05-07T04:51:06Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn1660-4601pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/238324pt_BR
dc.description.abstractResearch has shown the beneficial effects of naringin supplementation to adult rodents, which can ameliorate oxidative stress in disease models. However, evidence has demonstrated that polyphenol supplementation induced detrimental effects when consumed during sensitive periods of development, such as pregnancy. Therefore, we investigated the effect of maternal naringin supplementation during pregnancy on the offspring’s cerebral redox status. Pregnant Wistar rats were divided into control and naringin groups and supplemented from gestational day 15 to gestational day 21. On postnatal days 1, 7, and 21, offspring were euthanized, and the prefrontal cortex, hippocampus, striatum, and cerebellum dissected. On postnatal day 1, maternal naringin supplementation positively modulated the pups’ brain redox status. On postnatal day 7, a pro-oxidative milieu was observed in the offspring’s striatum and cerebellum in a sex-dependent manner, even though the prefrontal cortex and hippocampus were not negatively affected. Besides, the alterations observed on postnatal day 7 did not persist up to weaning. Our findings demonstrated that the effect induced by naringin supplementation in the brain redox status differed according to the period of development in which naringin was consumed since the beneficial effects usually found in the adult rodents became detrimental when the supplementation was applied during pregnancy.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofInternational journal of environmental research and public health. Basel. Vol. 18, no. 9 (May 2021), 4805, 20 p.pt_BR
dc.rightsOpen Accessen
dc.subjectFlavonoidsen
dc.subjectSuplementos nutricionaispt_BR
dc.subjectPregnancyen
dc.subjectOxirreduçãopt_BR
dc.subjectDOHaDen
dc.subjectGravidezpt_BR
dc.subjectFlavonoidespt_BR
dc.subjectBrainen
dc.subjectRedox statusen
dc.subjectAntioxidanten
dc.titleNaringin supplementation during pregnancy induces sex and region-specific alterations in the offspring’s brain redox statuspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001140294pt_BR
dc.type.originEstrangeiropt_BR


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