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dc.contributor.authorBrum, Pedro Ozoriopt_BR
dc.contributor.authorViola, Guilherme Danielskipt_BR
dc.contributor.authorGirardi, Carolina Saibropt_BR
dc.contributor.authorRibeiro, Camila Tiefenseept_BR
dc.contributor.authorBrum, Matheus Ozoriopt_BR
dc.contributor.authorGasparotto, Jucianopt_BR
dc.contributor.authorKrolow, Rachelpt_BR
dc.contributor.authorMoreira, Jose Claudio Fonsecapt_BR
dc.contributor.authorGelain, Daniel Penspt_BR
dc.date.accessioned2022-05-07T04:51:04Zpt_BR
dc.date.issued2022pt_BR
dc.identifier.issn0364-3190pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/238322pt_BR
dc.description.abstractNeuroblastoma is the most common extracranial solid tumour in childhood, originated from cells of the neural crest during the development of the Sympathetic Nervous System. Retinoids are vitamin-A derived differentiating agents utilised to avoid disease resurgence in high-risk neuroblastoma treatment. Several studies indicate that hypoxia—a common feature of the tumoural environment—is a key player in cell differentiation and proliferation. Hypoxia leads to the accumulation of the hypoxia-inducible factor-1α (HIF-1α). This work aims to investigate the effects of the selective inhibition of HIF-1α on the differentiation induced by retinoic acid in human neuroblastoma cells from the SH-SY5Y lineage to clarify its role in cell differentiation. Our results indicate that HIF-1α inhibition impairs RA-induced differentiation by reducing neuron-like phenotype and diminished immunolabeling and expression of differentiation markers.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofNeurochemical research. New York. Vol. 47, no. 2 (Feb. 2022), p. 409-421pt_BR
dc.rightsOpen Accessen
dc.subjectNeuroblastomapt_BR
dc.subjectHypoxiaen
dc.subjectSubunidade alfa do Fator 1 Induzível por Hipóxiapt_BR
dc.subjectDifferentiationen
dc.subjectNeuroblastomaen
dc.subjectTretinoínapt_BR
dc.subjectCanceren
dc.subjectDiferenciação celularpt_BR
dc.subjectHIF-1en
dc.subjectCélulas tumorais cultivadaspt_BR
dc.subjectSH-SY5Yen
dc.titleHypoxia-inducible factor-1α (HIF-1α) inhibition impairs retinoic acid-induced differentiation in SH-SY5Y neuroblastoma cells, leading to reduced neurite length and diminished gene expression related to cell differentiationpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001139658pt_BR
dc.type.originEstrangeiropt_BR


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