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dc.contributor.authorRohden, Francielipt_BR
dc.contributor.authorTeixeira, Luciele Varaschinipt_BR
dc.contributor.authorBernardi, Luis Pedropt_BR
dc.contributor.authorFerreira, Pâmela Cristina Lukasewiczpt_BR
dc.contributor.authorColombo, Marianapt_BR
dc.contributor.authorTeixeira, Geciéle Rodriguespt_BR
dc.contributor.authorOliveira, Fernanda dos Santos dept_BR
dc.contributor.authorLima, Elizabeth Obino Cirnept_BR
dc.contributor.authorGuma, Fátima Theresinha Costa Rodriguespt_BR
dc.contributor.authorSouza, Diogo Onofre Gomes dept_BR
dc.date.accessioned2022-04-13T04:51:16Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn1422-0067pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/237125pt_BR
dc.description.abstractIschemic stroke is a major cause of death and disability, intensely demanding innovative and accessible therapeutic strategies. Approaches presenting a prolonged period for therapeutic intervention and new treatment administration routes are promising tools for stroke treatment. Here, we evaluated the potential neuroprotective properties of nasally administered human adipose tissue mesenchymal stem cell (hAT-MSC)-derived extracellular vesicles (EVs) obtained from healthy individuals who underwent liposuction. After a single intranasal EV (200 µg/kg) administered 24 h after a focal permanent ischemic stroke in rats, a higher number of EVs, improvement of the blood–brain barrier, and re-stabilization of vascularization were observed in the recoverable peri-infarct zone, as well as a significant decrease in infarct volume. In addition, EV treatment recovered long-term motor (front paws symmetry) and behavioral impairment (short- and long-term memory and anxiety-like behavior) induced by ischemic stroke. In line with these findings, our work highlights hAT-MSC-derived EVs as a promising therapeutic strategy for stroke.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofInternational journal of molecular sciences. Basel. Vol. 22, no. 23 (Dec. 2021), 12860, 21 p.pt_BR
dc.rightsOpen Accessen
dc.subjectCélulas-tronco mesenquimaispt_BR
dc.subjectHuman adipose tissue mesenchymal stem cellsen
dc.subjectVesículas extracelularespt_BR
dc.subjectExtracellular vesiclesen
dc.subjectExperimental ischemic strokeen
dc.subjectAcidente vascular cerebralpt_BR
dc.subjectIntranasal treatmenten
dc.subjectAdministração intranasalpt_BR
dc.subjectNeuroprotectionen
dc.subjectRecuperação de função fisiológicapt_BR
dc.subjectFunctional recoveryen
dc.titleFunctional recovery caused by human adipose tissue mesenchymal stem cell-derived extracellular vesicles administered 24 h after stroke in ratspt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001138590pt_BR
dc.type.originEstrangeiropt_BR


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