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dc.contributor.authorScolari, Fernando Luíspt_BR
dc.contributor.authorHastenteufel, Laura Caroline Tavarespt_BR
dc.contributor.authorEinsfeld, Lídiapt_BR
dc.contributor.authorBueno, Juliapt_BR
dc.contributor.authorOrlandin, Leticiapt_BR
dc.contributor.authorClausell, Nadine Oliveirapt_BR
dc.contributor.authorGoldraich, Livia Adamspt_BR
dc.date.accessioned2022-04-13T04:50:25Zpt_BR
dc.date.issued2022pt_BR
dc.identifier.issn2296-858Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/237073pt_BR
dc.description.abstractPurpose: The coronavirus-2019 (COVID-19) infection is associated with a high risk of complications and death among heart transplant recipients. However, most cohorts are from high-income countries, while data from Latin America are sparse. Methods: This is a retrospective cohort of heart transplant recipients followed at a hospital in Rio Grande do Sul, Brazil, between March 1st 2020 and October 1st 2021. Results: Of the 62 heart transplant recipients on follow-up, 21 (34%) were infected by COVID-19, 58 (36-63) years of age, 67% male, body mass index of 26 (23-29) kg/m2, 48% with hypertension, 43% with chronic kidney disease, 5% with diabetes, within 2 (1-4) years of post-transplant follow-up. At presentation, the main symptoms were fever (62%), myalgia (33%), cough (33%), headache (33%), and dyspnea (19%). Hospitalization was required for 13 (62%) patients, with a time from first symptoms to the admission of 5 (1-12) days. In 38%, supplementary oxygen was needed, 19% required intensive care, and 10% mechanical ventilation. Three (14%) were infected after at least a first dose of COVID-19 vaccine. The main complications were bacterial pneumonia (38%), renal replacement therapy (19%), sepsis (10%) and venous thromboembolism (10%). Immunosuppression therapy was modified in 48%, with a reduction in the majority (89%). Two (10%) patients died in the hospital due to refractory hypoxemia and multiple organ dysfunction. The incidence of COVID-19 among transplant patients was comparable to the general population in the State of Rio Grande do Sul with a peak in December 2020. Conclusion: Heart transplant recipients shown a high rate of COVID-19 infection in Southern Brazil, with typical symptom presentation in most cases. There was an elevated rate of hospitalization, supplementary oxygen support, and complications. In-hospital lethality among infected heart transplanted recipients was similar to previously reported data worldwide despite the high rates of infection in Latin America.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofFrontiers in medicine. Lausanne. Vol.9 (Feb. 2022), 814952, 8 p.pt_BR
dc.rightsOpen Accessen
dc.subjectCOVID-19pt_BR
dc.subjectBrazilen
dc.subjectHeart transplanten
dc.subjectInfecções por coronaviruspt_BR
dc.subjectImmunosuppressionen
dc.subjectTransplante de coraçãopt_BR
dc.subjectBrasilpt_BR
dc.subjectInfectionen
dc.subjectImunossupressãopt_BR
dc.titleImpact of COVID-19 infection among heart transplant recipients : a southern brazilian experiencept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001138163pt_BR
dc.type.originEstrangeiropt_BR


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