Mostrar el registro sencillo del ítem

dc.contributor.authorDalepiane, Vanessa L. N.pt_BR
dc.contributor.authorFerreira, Daiane Nicoli Silvello dos Santospt_BR
dc.contributor.authorPaludo, Crislaine A.pt_BR
dc.contributor.authorRoisenberg, Israelpt_BR
dc.contributor.authorSimon, Danielpt_BR
dc.date.accessioned2010-06-05T04:17:27Zpt_BR
dc.date.issued2007pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/23401pt_BR
dc.description.abstractMatrix metalloproteinases (MMPs) play an important role in the pathogenesis of atherosclerosis, the pathology underlying the majority of coronary artery disease (CAD). In this study we tested the hypothesis that polymorphic variation in the MMP genes influences the risk of developing atherosclerosis. We analyzed functional polymorphisms in the promoter of the MMP-1, MMP-3, MMP-9 and MMP-12 genes in 183 Brazilian Caucasian individuals submitted to coronary angiography, of which 67 (37%) had normal coronary arteries (control group) and 116 (63%) had CAD (CAD patient group). The -1607 1G/2G MMP-1, -1171 5A/6A MMP-3, -1562 C/T MMP-9, -82 A/G MMP-12 polymorphisms were analyzed by PCR followed by restriction digestion. No significant differences were observed in allele frequencies between the CAD patients and controls. Haplotype analysis showed no differences between the CAD patients and controls. There was a significant difference in the severity of CAD, as assessed by the number of diseased vessels, in MMP-1 1G/1G homozygous individuals and in those homozygous for the 6A allele of the MMP-3 polymorphism. However, multivariate analysis showed that diabetes mellitus was the only variable independently associated with CAD severity. Our findings indicated that MMP polymorphisms have no significant impact on the risk and severity of CAD.en
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofGenetics and molecular biology. Ribeirão Preto. Vol. 30, no. 3 (Sept. 2007), p.505-510pt_BR
dc.rightsOpen Accessen
dc.subjectAtherosclerosisen
dc.subjectGenéticapt_BR
dc.subjectCoronary artery diseaseen
dc.subjectArteriosclerose coronáriapt_BR
dc.subjectPolimorfismopt_BR
dc.subjectGene polymorphismsen
dc.subjectMatrix metalloproteinasesen
dc.titleMatrix metalloproteinase gene polymorphisms in patients with coronary artery diseasept_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000603704pt_BR
dc.type.originNacionalpt_BR


Ficheros en el ítem

Thumbnail
   

Este ítem está licenciado en la Creative Commons License

Mostrar el registro sencillo del ítem