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dc.contributor.authorKvitko, Katiapt_BR
dc.contributor.authorGaspar, Pedro de Abreupt_BR
dc.contributor.authorTorres, Martiela Ribeiropt_BR
dc.contributor.authorHutz, Mara Helenapt_BR
dc.date.accessioned2010-06-05T04:17:25Zpt_BR
dc.date.issued2006pt_BR
dc.identifier.issn1415-4757pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/23392pt_BR
dc.description.abstractGene polymorphisms involved in the metabolism of drugs and chemical carcinogens seem to be responsible for differences in the susceptibility of individuals to cancer, but genetic population studies are needed to characterize these polymorphisms in different ethnic populations. We investigated polymorphisms of the cytochrome P450 (CYP) gene CYP1A1 and the glutathione S-transferase (GSTs) genes GSTM1, GSTT1 and GSTP1 in a sample of Afro- Brazilians from the southern Brazilian city of Porto Alegre to verify if there were ethnic differences compared to the polymorphisms of the same genes in a previously described sample of Brazilians of European descent from the same city. The allele frequencies detected in the Afro-Brazilian population investigated in this study were CYP1A1*2A (30%) and GSTP1*Val (42%) while the frequency of the GSTM1 null genotype was 34% and that of the GSTT1 null genotype was 28%. Significant differences in genotype distribution and allelic frequencies were detected between Brazilians of African and of European descent from Porto Alegre in terms of the polymorphisms CYP1A1*2A (p = 0.003), GSTP1-Ile105Val (p = 0.002) and theGSTM1 null genotype (p = 0.01) but there was no detectable significant difference in respect to GSTT1 null genotype frequenciesen
dc.format.mimetypeapplication/pdf
dc.language.isoengpt_BR
dc.relation.ispartofGenetics and molecular biology. Ribeirão Preto. Vol. 29, no. 4 (Dec. 2006), p. 613-616pt_BR
dc.rightsOpen Accessen
dc.subjectGenéticapt_BR
dc.subjectAfricanen
dc.subjectBrazilianen
dc.subjectPolimorfismopt_BR
dc.subjectCYP1A1en
dc.subjectEuropeanen
dc.subjectGSTsen
dc.subjectPorto Alegreen
dc.titleCYP1A1, GSTM1, GSTT1, GSTP1 polymorphisms in afro-brazilian grouppt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000566824pt_BR
dc.type.originNacionalpt_BR


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