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dc.contributor.authorLondero, Marina Dalla Barbapt_BR
dc.contributor.authorSousa, Mathias Hasse dept_BR
dc.contributor.authorPerin, Carolina Petrypt_BR
dc.contributor.authorCzepielewski, Letícia Sanguinettipt_BR
dc.contributor.authorClaudino, Felipe Cesar de Almeidapt_BR
dc.contributor.authorGama, Clarissa Severinopt_BR
dc.date.accessioned2021-11-19T04:46:34Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn2357-9730pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/232031pt_BR
dc.description.abstractFor years, the management of schizophrenia has represented a challenge for clinicians, with antipsychotic treatments usually resulting in relapses and new hospitalizations. Clozapine has been shown to be an effective medication for treatment-resistant schizophrenia (TRS), but is currently underused due to its potential side effects. Nevertheless, research has suggested that clozapine reduces future hospitalizations in patients with TRS. This study aims to verify the rates of hospitalizations in patients with TRS under long-term use of clozapine. We retrospectively analyzed clinical data from 52 individuals with TRS before and after the use of clozapine. The mean duration of treatment with and without clozapine was 6.6 (± 3.9) and 8.5 years (± 6.6), respectively. Patients had a median of 0.5 (0.74) hospitalizations per year before the use of clozapine and 0 (0.74) hospitalizations after it (p = 0.001). Therefore, the use of clozapine resulted in an expected reduction in the number of hospitalizations per year in individuals with TRS.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofClinical and biomedical research. Porto Alegre. Vol. 41, n. 2 (2021), p. 167-169pt_BR
dc.rightsOpen Accessen
dc.subjectSchizophreniaen
dc.subjectEsquizofreniapt_BR
dc.subjectTreatment-resistanten
dc.subjectHospitalização psiquiatricapt_BR
dc.subjectClozapineen
dc.subjectClozapinapt_BR
dc.subjectHospitalizationen
dc.titleClozapine use decreases the number of hospitalizations per year in patients with treatment-resistant schizophreniapt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001132484pt_BR
dc.type.originNacionalpt_BR


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