Evaluation of the association between KIR polymorphisms and systemic sclerosis : a meta-analysis
dc.contributor.author | Karimizadeh, Elham | pt_BR |
dc.contributor.author | Mostafaei, Shayan | pt_BR |
dc.contributor.author | Aslani, Saeed | pt_BR |
dc.contributor.author | Gharibdoost, Farhad | pt_BR |
dc.contributor.author | Xavier, Ricardo Machado | pt_BR |
dc.contributor.author | Salim, Patrícia Hartstein | pt_BR |
dc.contributor.author | Kavosi, Hoda | pt_BR |
dc.contributor.author | Farhadi, Elham | pt_BR |
dc.contributor.author | Mahmoudi, Mahdi | pt_BR |
dc.date.accessioned | 2021-10-14T04:29:48Z | pt_BR |
dc.date.issued | 2020 | pt_BR |
dc.identifier.issn | 2523-3106 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/230700 | pt_BR |
dc.description.abstract | Background: The results of investigations on the association between killer cell immunoglobulin-like receptor (KIR) gene polymorphisms and the risk of systemic sclerosis (SSc) are inconsistent. To comprehensively evaluate the influence of KIR polymorphisms on the risk of SSc, this meta-analysis was performed. Methods: A systematic literature search was performed in electronic databases including Scopus and PubMed/ MEDLINE to find all available studies involving KIR gene family polymorphisms and SSc risk prior to July 2019. Pooled odds ratios (ORs) and their corresponding 95% confidence intervals (CIs) were measured to detect associations between KIR gene family polymorphisms and SSc risk. Results: Five articles, comprising 571 patients and 796 healthy participants, evaluating the KIR gene family polymorphisms were included in the final meta-analysis according to the inclusion and exclusion criteria, and 16 KIR genes were assessed. None of the KIR genes were significantly associated with the risk of SSc. Conclusions: The current meta-analysis provides evidence that KIR genes might not be potential risk factors for SSc risk. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Advances in rheumatology. São Paulo. Vol. 60 (2020), 8, 8 p. | pt_BR |
dc.rights | Open Access | en |
dc.subject | Killer immunoglobulin-like receptors | en |
dc.subject | Doenças reumáticas | pt_BR |
dc.subject | Systemic sclerosis | en |
dc.subject | Escleroderma sistêmico | pt_BR |
dc.subject | Polymorphism | en |
dc.subject | Polimorfismo genético | pt_BR |
dc.subject | Biomarcadores | pt_BR |
dc.subject | Meta-analysis | en |
dc.subject | Fatores de risco | pt_BR |
dc.subject | Receptores KIR | pt_BR |
dc.subject | Revisão sistemática | pt_BR |
dc.subject | Metanálise | pt_BR |
dc.title | Evaluation of the association between KIR polymorphisms and systemic sclerosis : a meta-analysis | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001131519 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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