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dc.contributor.authorDiniz, Maria de Fátima Haueisen Sanderpt_BR
dc.contributor.authorBeleigoli, Alline Maria Rezendept_BR
dc.contributor.authorSchmidt, Maria Inêspt_BR
dc.contributor.authorDuncan, Bruce Bartholowpt_BR
dc.contributor.authorRibeiro, Antônio Luiz Pinhopt_BR
dc.contributor.authorVidigal, Pedro Guatimosimpt_BR
dc.contributor.authorBenseñor, Isabela Judith Martinspt_BR
dc.contributor.authorLotufo, Paulo Andradept_BR
dc.contributor.authorSantos, Itamar de Souzapt_BR
dc.contributor.authorGriep, Rosane Harterpt_BR
dc.contributor.authorBarreto, Sandhi Mariapt_BR
dc.date.accessioned2021-10-05T04:26:35Zpt_BR
dc.date.issued2020pt_BR
dc.identifier.issn0102-311Xpt_BR
dc.identifier.urihttp://hdl.handle.net/10183/230473pt_BR
dc.description.abstractHomeostasis model assessment of insulin resistance (HOMA-IR) is a method to measure insulin resistance. HOMA-IR cut-offs for identifying metabolic syndrome might vary across populations and body mass index (BMI) levels. We aimed to investigate HOMA-insulin resistance cut-offs that best discriminate individuals with insulin resistance and with metabolic syndrome for each BMI category in a large sample of adults without diabetes in the baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Among the 12,313 participants with mean age of 51.2 (SD 8.9) years, the prevalence of metabolic syndrome was 34.6%, and 60.1% had overweight or obesity. The prevalence of metabolic syndrome among normal weight, overweight and obesity categories were, respectively, 13%, 43.2% and 60.7%. The point of maximum combined sensitivity and specificity of HOMA-IR to discriminate the metabolic syndrome was 2.35 in the whole sample, with increasing values at higher BMI categories. This investigation contributes to better understanding HOMA-IR values associated with insulin resistance and metabolic syndrome in a large Brazilian adult sample, and that use of cut-off points according to ROC curve may be the better strategy. It also suggests that different values might be appropriate across BMI categories.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofCadernos de saúde pública = Reports in public health. Rio de Janeiro, RJ. Vol. 36, n. 8 (2020), e00072120, p. 1-7.pt_BR
dc.rightsOpen Accessen
dc.subjectEstudos de coortespt_BR
dc.subjectMetabolic syndromeen
dc.subjectSíndrome metabólicapt_BR
dc.subjectInsulin resistanceen
dc.subjectResistência à insulinapt_BR
dc.subjectCohort studiesen
dc.titleHomeostasis model assessment of insulin resistance (HOMA-IR) and metabolic syndrome at baseline of a multicentric Brazilian cohort : ELSA-Brasil studypt_BR
dc.title.alternativeModelo de avaliação da homeostase de resistência à insulina (HOMA-IR) e síndrome metabólica na linha de base de uma coorte brasileira multicêntrica : estudo ELSA-Brasilpt
dc.title.alternativeModelo homeostático para evaluar la resistencia a la insulina (HOMA-IR) y síndrome metabólico en la línea de base de una cohorte brasileña multicéntrica : estudio ELSA-Brasiles
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001131140pt_BR
dc.type.originNacionalpt_BR


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