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dc.contributor.authorPrichula, Janirapt_BR
dc.contributor.authorBarros, Muriel Primon dept_BR
dc.contributor.authorLuz, Romeu C. Z.pt_BR
dc.contributor.authorCastro, Ícaro Maia Santos dept_BR
dc.contributor.authorPaim, Thiago Galvão da Silvapt_BR
dc.contributor.authorTavares, Mauríciopt_BR
dc.contributor.authorD'Azevedo, Pedro Alvespt_BR
dc.contributor.authorFrazzon, Jeversonpt_BR
dc.contributor.authorFrazzon, Ana Paula Guedespt_BR
dc.contributor.authorSeixas, Adrianapt_BR
dc.contributor.authorGilmore, Michael S.pt_BR
dc.date.accessioned2021-09-03T04:27:58Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn1660-3397pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/229534pt_BR
dc.description.abstractNew ecosystems are being actively mined for new bioactive compounds. Because of the large amount of unexplored biodiversity, bacteria from marine environments are especially promising. Further, host-associated microbes are of special interest because of their low toxicity and compatibility with host health. Here, we identified and characterized biosynthetic gene clusters encoding antimicrobial compounds in host-associated enterococci recovered from fecal samples of wild marine animals remote from human-affected ecosystems. Putative biosynthetic gene clusters in the genomes of 22 Enterococcus strains of marine origin were predicted using antiSMASH5 and Bagel4 bioinformatic software. At least one gene cluster encoding a putative bioactive compound precursor was identified in each genome. Collectively, 73 putative antimicrobial compounds were identified, including 61 bacteriocins (83.56%), 10 terpenes (13.70%), and 2 (2.74%) related to putative nonribosomal peptides (NRPs). Two of the species studied, Enterococcus avium and Enterococcus mundtti, are rare causes of human disease and were found to lack any known pathogenic determinants but yet possessed bacteriocin biosynthetic genes, suggesting possible additional utility as probiotics. Wild marine animal-associated enterococci from human-remote ecosystems provide a potentially rich source for new antimicrobial compounds of therapeutic and industrial value and potential probiotic application.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofMarine drugs. Basel. Vol. 19, no. 6 (June 2021), 328, 21 p.pt_BR
dc.rightsOpen Accessen
dc.subjectFauna marinhapt_BR
dc.subjectEnterococcien
dc.subjectGenome-wide analysisen
dc.subjectEnterococcuspt_BR
dc.subjectBacteriocinsen
dc.subjectAnti-infecciosospt_BR
dc.subjectBacteriocinaspt_BR
dc.subjectProbioticsen
dc.subjectWild marine speciesen
dc.subjectFamília multigênicapt_BR
dc.subjectGenoma microbianopt_BR
dc.titleGenome mining for antimicrobial compounds in wild marine animals-associated Enterococcipt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001130852pt_BR
dc.type.originEstrangeiropt_BR


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