Mostrar el registro sencillo del ítem
Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis
dc.contributor.author | Colombo, Natália Beatriz Rigoldi | pt_BR |
dc.contributor.author | Rangel, Maristela Peres | pt_BR |
dc.contributor.author | Hage, Márcia | pt_BR |
dc.contributor.author | Gelain, Daniel Pens | pt_BR |
dc.contributor.author | Barbeiro, Denise Frediani | pt_BR |
dc.contributor.author | Grisolia, Cesar Koppe | pt_BR |
dc.contributor.author | Parra Cuentas, Edwin Roger | pt_BR |
dc.contributor.author | Capelozzi, Vera L. | pt_BR |
dc.date.accessioned | 2021-08-20T04:13:16Z | pt_BR |
dc.date.issued | 2015 | pt_BR |
dc.identifier.issn | 0100-879X | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/226001 | pt_BR |
dc.description.abstract | The antioxidant effects of Caryocar brasiliense Camb, commonly known as the pequi fruit, have not been evaluated to determine their protective effects against oxidative damage in lung carcinogenesis. In the present study, we evaluated the role of pequi fruit against urethane-induced DNA damage and oxidative stress in forty 8–12 week old male BALB/C mice. An in vivo comet assay was performed to assess DNA damage in lung tissues and changes in lipid peroxidation and redox cycle antioxidants were monitored for oxidative stress. Prior supplementation with pequi oil or its extract (15 mL, 60 days) significantly reduced urethane-induced oxidative stress. A protective effect against DNA damage was associated with the modulation of lipid peroxidation and low protein and gene expression of nitric oxide synthase. These findings suggest that the intake of pequi fruit might protect against in vivo genotoxicity and oxidative stress. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Brazilian journal of medical and biological research = Revista brasileira de pesquisas médicas e biológicas. Ribeirão Preto, SP. Vol. 48, no. 9 (2015), p. 852-862 | pt_BR |
dc.rights | Open Access | en |
dc.subject | Neoplasias pulmonares | pt_BR |
dc.subject | Caryocar brasiliense Camb | en |
dc.subject | Estresse oxidativo | pt_BR |
dc.subject | Oxidative stress | en |
dc.subject | Lung cancer | en |
dc.subject | Pequi | pt_BR |
dc.subject | Urethane | en |
dc.subject | Molecular biology | en |
dc.title | Caryocar brasiliense camb protects against genomic and oxidative damage in urethane-induced lung carcinogenesis | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001005279 | pt_BR |
dc.type.origin | Nacional | pt_BR |
Ficheros en el ítem
Este ítem está licenciado en la Creative Commons License
-
Artículos de Periódicos (39333)Ciencias Biologicas (3061)