Remarkable anti-trichomonas vaginalis activity of plants traditionally used by the MbYá-guarani indigenous group in Brazil
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Date
2013Type
Subject
Abstract
Trichomonas vaginalis, a flagellate protozoan, is the causative agent of trichomonosis, the most common nonviral sexually transmitted disease worldwide. Taking into account the increased prevalence of metronidazole-resistant isolates, alternative drugs are essential for the successful treatment. Natural products are the source of most new drugs, and popular wisdom about the use of medicinal plants is a powerful tool in this search. In this study, the activity of 10 medicinal plants extensively ...
Trichomonas vaginalis, a flagellate protozoan, is the causative agent of trichomonosis, the most common nonviral sexually transmitted disease worldwide. Taking into account the increased prevalence of metronidazole-resistant isolates, alternative drugs are essential for the successful treatment. Natural products are the source of most new drugs, and popular wisdom about the use of medicinal plants is a powerful tool in this search. In this study, the activity of 10 medicinal plants extensively used in daily life by Mbya-Guarani indigenous group was evaluated against seven different ´ T. vaginalis isolates. Among the aqueous extracts tested, Verbena sp. (Guachu ka’a in Mbya-Guarani language) and ´ Campomanesia xanthocarpa (Guavira in Mbya-Guarani language) ´ showed the highest activity against T. vaginalis with MIC value of 4.0 mg/mL reaching 100% of efficacy against the parasite. The kinetic growth assays showed that the extracts promoted complete growth abolishment after 4 h of incubation. In addition, the extracts tested did not promote a significant hemolytic activity against human erythrocytes. Our results show for the first time the potential activity of Verbena sp. and C. xanthocarpa against T. vaginalis. In addition, this study demonstrates that indigenous knowledge is an important source of new prototype antiprotozoal agents. ...
In
Journal of biomedicine and biotechnology. Cairo. Vol. 2013, p. 1-7
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Foreign
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Journal Articles (39552)Health Sciences (10602)
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