Elevated serum interleukin-6 is predictive of coronary artery disease in intermediate risk overweight patients referred for coronary angiography
dc.contributor.author | Wainstein, Marco Vugman | pt_BR |
dc.contributor.author | Mossmann, Márcio | pt_BR |
dc.contributor.author | Araújo, Gustavo Neves de | pt_BR |
dc.contributor.author | Gonçalves, Sandro Cadaval | pt_BR |
dc.contributor.author | Gravina, Gabriela Leal | pt_BR |
dc.contributor.author | Sangalli, Marlei | pt_BR |
dc.contributor.author | Veadrigo, Francine | pt_BR |
dc.contributor.author | Matte, Roselene | pt_BR |
dc.contributor.author | Reich, Rejane | pt_BR |
dc.contributor.author | Costa, Fernanda Guimarães | pt_BR |
dc.contributor.author | Andrades, Michael Everton | pt_BR |
dc.contributor.author | Silva, Antônio Marcos Vargas da | pt_BR |
dc.contributor.author | Bertoluci, Marcello Casaccia | pt_BR |
dc.date.accessioned | 2021-07-21T04:24:04Z | pt_BR |
dc.date.issued | 2017 | pt_BR |
dc.identifier.issn | 1758-5996 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/10183/224266 | pt_BR |
dc.description.abstract | Background: Interleukin-6 (IL-6) plays a central role in atherosclerosis and infammation. It may improve risk prediction in patients at intermediate cardiovascular risk. Objective: To analyze the impact of serum IL-6 in predicting early angiographic coronary artery disease in patients at intermediate cardiovascular risk with chest pain. Methods: In a cross-sectional study, patients referred for coronary angiography due to suspected coronary artery disease (CAD) were included. Coronary artery disease was defned as the presence of at least 30% stenosis in one or more coronary artery. Severity of CAD was classifed by the anatomic burden score. Performance of serum IL-6 assay was compared with ACC/AHA atherosclerotic cardiovascular disease (ASCVD) risk score and hs-CRP through receiver operating characteristic (ROC) curves. Results: We have included 48 patients with a mean 10-year ASCVD risk of 10.0 ± 6.8%. The prevalence of CAD was 72.9%. The presence of CAD was associated with higher mean levels of IL-6 (p = 0.025). Patients with CAD had signifcantly more overweight than subjects without CAD. In 27% of patients, IL-6 was >1.0 pg/mL and 100% of these patients had CAD, while only 64% in those with IL-6 <1.0 pg/mL, corresponding to a positive predictive value of 100% (p = 0.015). The area under the receiver operating characteristic (ROC) curve of IL-6, hs-CRP and ASCVD were respectively 0.72, 0.60 and 0.54. Intermediate risk patients with IL-6 >1.0 pg/mL were further reclassifed into ASCVD high risk due to the presence of coronary lesions. Conclusion: In intermediate risk patients referred for coronary angiography, a serum IL-6 level above 1 pg/mL is predictive of signifcant CAD. IL-6 determination may be useful to reclassify ASCVD intermediate risk patients into higher risk categories. | en |
dc.format.mimetype | application/pdf | pt_BR |
dc.language.iso | eng | pt_BR |
dc.relation.ispartof | Diabetology & metabolic syndrome. London : BioMed Central. Vol. 9 (Sept. 2017), p. 67 (7 f.) | pt_BR |
dc.rights | Open Access | en |
dc.subject | Soro | pt_BR |
dc.subject | Interleukin-6 | en |
dc.subject | Risk factors | en |
dc.subject | Interleucina-6 | pt_BR |
dc.subject | Coronary angiography | en |
dc.subject | Doença da artéria coronariana | pt_BR |
dc.subject | Infammation | en |
dc.subject | Fatores de risco | pt_BR |
dc.subject | Coronary artery disease | en |
dc.subject | Sobrepeso | pt_BR |
dc.subject | Angiografia coronária | pt_BR |
dc.subject | Pacientes | pt_BR |
dc.title | Elevated serum interleukin-6 is predictive of coronary artery disease in intermediate risk overweight patients referred for coronary angiography | pt_BR |
dc.type | Artigo de periódico | pt_BR |
dc.identifier.nrb | 001058215 | pt_BR |
dc.type.origin | Nacional | pt_BR |
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