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dc.contributor.authorSchonwald, Suzana Veigapt_BR
dc.contributor.authorCarvalho, Diego Zaquerapt_BR
dc.contributor.authorSanta Helena, Emerson Luiz dept_BR
dc.contributor.authorLemke, Neypt_BR
dc.contributor.authorGerhardt, Gunther Johannes Lewczukpt_BR
dc.date.accessioned2021-07-21T04:23:35Zpt_BR
dc.date.issued2012pt_BR
dc.identifier.issn1471-2202pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/224232pt_BR
dc.description.abstractBackground: Sleep spindles, as detected on scalp electroencephalography (EEG), are considered to be markers of thalamo-cortical network integrity. Since obstructive sleep apnea (OSA) is a known cause of brain dysfunction, the aim of this study was to investigate sleep spindle frequency distribution in OSA. Seven non-OSA subjects and 21 patients with OSA (11 mild and 10 moderate) were studied. A matching pursuit procedure was used for automatic detection of fast (≥ 13Hz) and slow (< 13Hz) spindles obtained from 30min samples of NREM sleep stage 2 taken from initial, middle and final night thirds (sections I, II and III) of frontal, central and parietal scalp regions. Results: Compared to non-OSA subjects, Moderate OSA patients had higher central and parietal slow spindle percentage (SSP) in all night sections studied, and higher frontal SSP in sections II and III. As the night progressed, there was a reduction in central and parietal SSP, while frontal SSP remained high. Frontal slow spindle percentage in night section III predicted OSA with good accuracy, with OSA likelihood increased by 12.1% for every SSP unit increase (OR 1.121, 95% CI 1.013 - 1.239, p=0.027). Conclusions: These results are consistent with diffuse, predominantly frontal thalamo-cortical dysfunction during sleep in OSA, as more posterior brain regions appear to maintain some physiological spindle frequency modulation across the night. Displaying changes in an opposite direction to what is expected from the aging process itself, spindle frequency appears to be informative in OSA even with small sample sizes, and to represent a sensitive electrophysiological marker of brain dysfunction in OSA.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofBMC neuroscience. London. Vol. 13 (Jul. 2012), 89, [12] p.pt_BR
dc.rightsOpen Accessen
dc.subjectTime seriesen
dc.subjectApneia obstrutiva do sonopt_BR
dc.subjectMatching pursuiten
dc.subjectEEGen
dc.subjectSleep spindlesen
dc.subjectOSAen
dc.titleTopography-specific spindle frequency changes in obstructive sleep apneapt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb000869287pt_BR
dc.type.originEstrangeiropt_BR


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