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dc.contributor.authorBarbé-Tuana, Florencia Maríapt_BR
dc.contributor.authorGrun, Lucas Kichpt_BR
dc.contributor.authorLima, Vinícius Pierdonápt_BR
dc.contributor.authorParisi, Mariana Migliorinipt_BR
dc.contributor.authorFriedrich, Frederico Orlandopt_BR
dc.contributor.authorGuma, Fátima Theresinha Costa Rodriguespt_BR
dc.contributor.authorPinto, Leonardo Araujopt_BR
dc.contributor.authorStein, Renato Tetelbompt_BR
dc.contributor.authorPitrez, Paulo Marcio Condessapt_BR
dc.contributor.authorJones, Marcus Herbertpt_BR
dc.date.accessioned2021-04-06T04:19:19Zpt_BR
dc.date.issued2021pt_BR
dc.identifier.issn1945-4589pt_BR
dc.identifier.urihttp://hdl.handle.net/10183/219447pt_BR
dc.description.abstractSevere therapy-resistant asthma (STRA) is closely associated with distinct clinical and inflammatory pheno-endotypes, which may contribute to the development of age-related comorbidities. Evidence has demonstrated a contribution of accelerated telomere shortening on the poor prognosis of respiratory diseases in adults. Eotaxin-1 (CCL11) is an important chemokine for eosinophilic recruitment and the progression of asthma. In the last years has also been proposed as an age-promoting factor. This study aimed to investigate the association of relative telomere length (rTL) and eotaxin-1 in asthmatic children. Children aged 8-14 years (n=267) were classified as healthy control (HC, n=126), mild asthma (MA, n=124) or severe therapy-resistant asthma (STRA, n=17). rTL was performed by qPCR from peripheral blood. Eotaxin-1 was quantified by ELISA from fresh-frozen plasma. STRA had shorter telomeres compared to HC (p=0.02) and MA (p=0.006). Eotaxin-1 levels were up-regulated in STRA [median; IQR25-75)] [(1,190 pg/mL; 108–2,510)] compared to MA [(638 pg/mL; 134–1,460)] (p=0.03) or HC [(627 pg/mL; 108–1,750)] (p<0.01). Additionally, shorter telomeres were inversely correlated with eotaxin-1 levels in STRA (r=-0.6, p=0.013). Our results suggest that short telomeres and up-regulated eotaxin-1, features of accelerated aging, could prematurely contribute to a senescent phenotype increasing the risk for early development of age-related diseases in asthma.en
dc.format.mimetypeapplication/pdfpt_BR
dc.language.isoengpt_BR
dc.relation.ispartofAging. Albany. Vol. 13, no. 2 (Jan. 2021), p. 1686-1691pt_BR
dc.rightsOpen Accessen
dc.subjectAsmapt_BR
dc.subjectTelomere lengthen
dc.subjectQuimiocina CCL11pt_BR
dc.subjectCCL11en
dc.subjectHomeostase do telômeropt_BR
dc.subjectSevere asthmaen
dc.subjectInflammagingen
dc.subjectCriançapt_BR
dc.subjectSenescenceen
dc.titleShorter telomeres in children with severe asthma, an indicative of accelerated agingpt_BR
dc.typeArtigo de periódicopt_BR
dc.identifier.nrb001123360pt_BR
dc.type.originEstrangeiropt_BR


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